Home Angiogenesis BTK inhibitor N-piperidine Ibrutinib hydrochloride For research use only.

N-piperidine Ibrutinib hydrochloride

N-piperidine Ibrutinib hydrochloride, a reversible Ibrutinib derivative, is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively.

N-piperidine Ibrutinib hydrochloride Chemical Structure

N-piperidine Ibrutinib hydrochloride Chemical Structure

CAS No. 2231747-18-3

Purity & Quality Control

Batch: E220101 Water]85 mg/mL]false]DMSO]11 mg/mL]false]Ethanol]Insoluble]false Purity: 99.09%
99.09

N-piperidine Ibrutinib hydrochloride Related Products

Signaling Pathway

BTK Signaling Pathways

BTK Signaling Pathway

Biological Activity

Description N-piperidine Ibrutinib hydrochloride, a reversible Ibrutinib derivative, is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively.
Targets
C481S BTK [1]
(in vitro kinase inhibition assay)		 WT BTK [1]
(in vitro kinase inhibition assay)
30.7 nM 51.0 nM

Chemical Information & Solubility

Molecular Weight 422.91 Formula

C22H22N6O.ClH
CAS No. 2231747-18-3 SDF --
Smiles Cl.NC1=C2C(=NC=N1)[N](N=C2C3=CC=C(OC4=CC=CC=C4)C=C3)C5CCNCC5
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 85 mg/mL

DMSO : 11 mg/mL ( (26.01 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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