Home Metabolism Mitochondrial Metabolism modulator Mitochondrial Fusion Promoter M1 For research use only.

Mitochondrial Fusion Promoter M1

Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator that increases the expression of mitofusin 2, a mitochondrial outer membrane fusion protein, reduces brain mitochondrial dysfunction. Mitochondrial fusion promoter M1 alleviates brain damage in rats with cardiac ischemia/reperfusion injury.

Mitochondrial Fusion Promoter M1 Chemical Structure

Mitochondrial Fusion Promoter M1 Chemical Structure

CAS No. 219315-22-7

Purity & Quality Control

Mitochondrial Fusion Promoter M1 Related Products

Biological Activity

Description Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator that increases the expression of mitofusin 2, a mitochondrial outer membrane fusion protein, reduces brain mitochondrial dysfunction. Mitochondrial fusion promoter M1 alleviates brain damage in rats with cardiac ischemia/reperfusion injury.
In vitro
In vitro

Mitochondrial Fusion Promoter M1 prevents the cholesterol mediated blunting of cellular respiration and potentiates Glucose stimulated insulin secretion which is abolished in pancreatic beta cells on cholesterol accumulation.[2]
Cell Research Cell lines BRIN-BD11 cells
Concentrations 20 μM
Incubation Time 12 h
Method

BRIN-BD11 cells are first treated with Mitochondrial Fusion Promoter M1 for 12 h and then cholesterol (160 μM) is added to the media for another 12 h before various assays.
In Vivo
In vivo

Pretreatment with Mitochondrial Fusion Promoter M1 effectively increases the expression of mitofusin 2, a mitochondrial outer membrane fusion protein, reduces brain mitochondrial dysfunction, BBB breakdown, macrophage infiltration, apoptosis, and AD-related proteins in rats following cardiac I/R injury.[1]

Chemical Information & Solubility

Molecular Weight 364.05 Formula

C14H10Cl4N2O
CAS No. 219315-22-7 SDF --
Smiles CC(=N/NC1=C(Cl)C=C(Cl)C=C1Cl)\C2=C(O)C=CC(=C2)Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 73 mg/mL ( (200.52 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Mitochondrial Fusion Promoter M1 | Mitochondrial Fusion Promoter M1 supplier | purchase Mitochondrial Fusion Promoter M1 | Mitochondrial Fusion Promoter M1 cost | Mitochondrial Fusion Promoter M1 manufacturer | order Mitochondrial Fusion Promoter M1 | Mitochondrial Fusion Promoter M1 distributor