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Formula | C14H10Cl4N2O |
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Molecular Weight | 364.05 | CAS No. | 219315-22-7 | |
Solubility (25°C)* | In vitro | DMSO | 73 mg/mL (200.52 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator that increases the expression of mitofusin 2, a mitochondrial outer membrane fusion protein, reduces brain mitochondrial dysfunction. Mitochondrial fusion promoter M1 alleviates brain damage in rats with cardiac ischemia/reperfusion injury. |
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In vitro | Mitochondrial Fusion Promoter M1 prevents the cholesterol mediated blunting of cellular respiration and potentiates Glucose stimulated insulin secretion which is abolished in pancreatic beta cells on cholesterol accumulation.[2] |
In vivo | Pretreatment with Mitochondrial Fusion Promoter M1 effectively increases the expression of mitofusin 2, a mitochondrial outer membrane fusion protein, reduces brain mitochondrial dysfunction, BBB breakdown, macrophage infiltration, apoptosis, and AD-related proteins in rats following cardiac I/R injury.[1] |
Cell Assay: |
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Dysregulation of mitochondrial dynamics and mitophagy are involved in high-fat diet-induced steroidogenesis inhibition [ J Lipid Res, 2024, 65(10):100639] | PubMed: 39236859 |
SIRT3 promotes metabolic maturation of human iPSC-derived cardiomyocytes via OPA1-controlled mitochondrial dynamics [ Free Radic Biol Med, 2023, 195:270-282] | PubMed: 36596388 |
The effect of mitochondrial fusion on chondrogenic differentiation of cartilage progenitor/stem cells via Notch2 signal pathway [ Stem Cell Res Ther, 2022, 13(1):127] | PubMed: 35337368 |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.