Home Immunology & Inflammation COX inhibitor Metamizole sodium hydrate For research use only.

Metamizole sodium hydrate

Synonyms: Dipyrone sodium hydrate

Metamizole (Dipyrone) sodium hydrate is a potent inhitior of cyclooxygenase (COX) with strong analgesic as well as antipyretic and spasmolytic properties.

Metamizole sodium hydrate Chemical Structure

Metamizole sodium hydrate Chemical Structure

CAS No. 5907-38-0

Purity & Quality Control

Batch: S443501 DMSO]70 mg/mL]false]Water]70 mg/mL]false]Ethanol]35 mg/mL]false Purity: 99.85%
99.85

Metamizole sodium hydrate Related Products

Signaling Pathway

COX Signaling Pathways

COX Signaling Pathway

Biological Activity

Description Metamizole (Dipyrone) sodium hydrate is a potent inhitior of cyclooxygenase (COX) with strong analgesic as well as antipyretic and spasmolytic properties.
Targets
COX [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02660177 Completed
Children|Pain|Surgery
University Children''s Hospital Basel
 April 2016 Phase 2
NCT02148939 Completed
Ischemic Stroke
Heinrich-Heine University Duesseldorf
 May 2014 --
NCT02712268 Completed
Elderly Internal Medicine Patients
University Hospital Basel Switzerland
 September 2013 Not Applicable
NCT00410332 Unknown status
Post-Tonsillectomy
Shaare Zedek Medical Center
 March 2011 Phase 3
NCT00799149 Completed
Knee Arthroscopy
Meir Medical Center
 June 2006 Phase 4
NCT00635037 Completed
Myofascial Pain Syndromes
Federal University of São Paulo
 June 2004 Not Applicable

Chemical Information & Solubility

Molecular Weight 351.35 Formula

C13H18N3NaO5S
CAS No. 5907-38-0 SDF --
Smiles O.[Na+].CN(C[S]([O-])(=O)=O)C1=C(C)N(C)N(C1=O)C2=CC=CC=C2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 70 mg/mL ( (199.23 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 70 mg/mL

Ethanol : 35 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Metamizole sodium hydrate | Metamizole sodium hydrate supplier | purchase Metamizole sodium hydrate | Metamizole sodium hydrate cost | Metamizole sodium hydrate manufacturer | order Metamizole sodium hydrate | Metamizole sodium hydrate distributor