Home Cytoskeletal Signaling Microtubule Associated inhibitor - ADC Cytotoxin chemical DM1 (Mertansine) For research use only.

DM1 (Mertansine)

Synonyms: Maytansinoid DM1

DM1 (Mertansine), an antibody-conjugatable maytansinoid, is a selective microtubule inhibitor that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC).Solutions are unstable and should be fresh-prepared.

DM1 (Mertansine) Chemical Structure

DM1 (Mertansine) Chemical Structure

CAS No. 139504-50-0

Purity & Quality Control

Batch: S677301 DMSO]50 mg/mL]false]Ethanol]2 mg/mL]false]Water]Insoluble]false Purity: 99.84%
99.84

DM1 (Mertansine) Related Products

Signaling Pathway

Microtubule Associated Signaling Pathways

Microtubule Associated Signaling Pathway

Biological Activity

Description DM1 (Mertansine), an antibody-conjugatable maytansinoid, is a selective microtubule inhibitor that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC).Solutions are unstable and should be fresh-prepared.
Targets
Microtubule [1]
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NCT06138743 Recruiting
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Arrowhead Pharmaceuticals
 March 4 2024 Phase 1
NCT05532813 Not yet recruiting
Steinert''s Disease|Myotonic Dystrophy 1|Metformin
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Myotonic Dystrophy 1
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NCT06270186 Withdrawn
Myotonic Dystrophy 1
Centre Hospitalier Universitaire de Nice
 November 2023 Not Applicable
NCT05945927 Recruiting
Breast Cancer
Hoffmann-La Roche
 September 13 2023 --

Chemical Information & Solubility

Molecular Weight 738.29 Formula

C35H48ClN3O10S
CAS No. 139504-50-0 SDF --
Smiles COC1\C=C\C=C(C)\CC2=CC(=C(Cl)C(=C2)OC)N(C)C(=O)CC(OC(=O)C(C)N(C)C(=O)CCS)C3(C)OC3C(C)C4CC1(O)NC(=O)O4
Storage (From the date of receipt) 3 years-20°C powder Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.

In vitro
Batch:

DMSO : 50 mg/mL ( (67.72 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 2 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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