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Luliconazole

Name: Luliconazole
Brand: Selleck Chemicals
SKU: S4258
Rating: 5 (1 reviews)

Synonyms: NND 502

Catalog No.S4258 Purity:99.99%

Luliconazole(NND 502) is a broad-spectrum antifungal drug.

Luliconazole Chemical Structure

CAS No. 187164-19-8

Purity & Quality Control

Batch: S425801 DMSO]71 mg/mL]false]Ethanol]5 mg/mL]false]Water]Insoluble]false Purity: 99.99%

99.99

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Biological Activity

Description	Luliconazole(NND 502) is a broad-spectrum antifungal drug.

In vitro
In vitro	Luliconazole inhibits growth of all filamentous fungi except zygomycetes at low concentrations (MIC, ≦0.004–0.125 µg/ml), with dermatophytes being most susceptible (MIC, ≦0.004–0.008 µg/ml). ^[1] Luliconazole demonstrates greater potency against Trichophyton spp. (MIC range: [2]

In Vivo
In vivo	Luliconazole (1% cream) treatment produces a clinical effi cacy somewhat below terbinafine with 50.8% in a guinea pig model of dermatophytosis. Luliconazole (1% cream) treated guinea pigs have hairs covered with amorphous debris and a small number of conidia are detected. The improved efficacy of Luliconazole over Lanoconazole is likely due to Luliconazole being strictly an R-enantiomer while lanoconazole is a racemic mixture. ^[3]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT05110638	Active not recruiting	Onychomycosis of Toenail	SATO Pharmaceutical Co. Ltd.	September 13 2021	Phase 1
NCT02767947	Completed	Tinea Corporis	Bausch Health Americas Inc.	February 8 2016	Phase 4
NCT02767271	Completed	Tinea Pedis\|Tinea Cruris	Bausch Health Americas Inc.	December 2 2015	Phase 4
NCT02394340	Completed	Tinea Pedis\|Tinea Cruris	Bausch & Lomb Incorporated\|Bausch Health Americas Inc.	February 3 2015	Phase 4

References

Chemical Information & Solubility

Molecular Weight	354.28	Formula	C₁₄H₉Cl₂N₃S₂
CAS No.	187164-19-8	SDF	Download Luliconazole SDF
Smiles	C1C(SC(=C(C#N)N2C=CN=C2)S1)C3=C(C=C(C=C3)Cl)Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 71 mg/mL ( (200.4 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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