Home Microbiology Fungal inhibitor Luliconazole For research use only.

Luliconazole

Synonyms: NND 502

Luliconazole(NND 502) is a broad-spectrum antifungal drug.

Luliconazole Chemical Structure

Luliconazole Chemical Structure

CAS No. 187164-19-8

Purity & Quality Control

Batch: S425801 DMSO]71 mg/mL]false]Ethanol]5 mg/mL]false]Water]Insoluble]false Purity: 99.99%
99.99

Luliconazole Related Products

Biological Activity

Description Luliconazole(NND 502) is a broad-spectrum antifungal drug.
In vitro
In vitro

Luliconazole inhibits growth of all filamentous fungi except zygomycetes at low concentrations (MIC, ≦0.004–0.125 µg/ml), with dermatophytes being most susceptible (MIC, ≦0.004–0.008 µg/ml). [1] Luliconazole demonstrates greater potency against Trichophyton spp. (MIC range: [2]
In Vivo
In vivo

Luliconazole (1% cream) treatment produces a clinical effi cacy somewhat below terbinafine with 50.8% in a guinea pig model of dermatophytosis. Luliconazole (1% cream) treated guinea pigs have hairs covered with amorphous debris and a small number of conidia are detected. The improved efficacy of Luliconazole over Lanoconazole is likely due to Luliconazole being strictly an R-enantiomer while lanoconazole is a racemic mixture. [3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05110638 Active not recruiting
Onychomycosis of Toenail
SATO Pharmaceutical Co. Ltd.
 September 13 2021 Phase 1
NCT02767947 Completed
Tinea Corporis
Bausch Health Americas Inc.
 February 8 2016 Phase 4
NCT02767271 Completed
Tinea Pedis|Tinea Cruris
Bausch Health Americas Inc.
 December 2 2015 Phase 4
NCT02394340 Completed
Tinea Pedis|Tinea Cruris
Bausch & Lomb Incorporated|Bausch Health Americas Inc.
 February 3 2015 Phase 4

Chemical Information & Solubility

Molecular Weight 354.28 Formula

C14H9Cl2N3S2
CAS No. 187164-19-8 SDF Download Luliconazole SDF
Smiles C1C(SC(=C(C#N)N2C=CN=C2)S1)C3=C(C=C(C=C3)Cl)Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 71 mg/mL ( (200.4 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Luliconazole | Luliconazole ic50 | Luliconazole price | Luliconazole cost | Luliconazole solubility dmso | Luliconazole purchase | Luliconazole manufacturer | Luliconazole research buy | Luliconazole order | Luliconazole mouse | Luliconazole chemical structure | Luliconazole mw | Luliconazole molecular weight | Luliconazole datasheet | Luliconazole supplier | Luliconazole in vitro | Luliconazole cell line | Luliconazole concentration | Luliconazole nmr