Home Immunology & Inflammation AhR agonist ITE For research use only.

ITE

Synonyms: 2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester

ITE (2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester) is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) that directly binds to AHR with a Ki of 3 nM.

ITE Chemical Structure

ITE Chemical Structure

CAS No. 448906-42-1

Purity & Quality Control

Batch: E014301 DMSO]57 mg/mL]false]Ethanol]2 mg/mL]false]Water]Insoluble]false Purity: 99.64%
99.64

ITE Related Products

Biological Activity

Description

ITE (2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester) is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) that directly binds to AHR with a Ki of 3 nM.
Targets
AhR [1]
3 nM(Ki)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04262271 Completed
Respiratory Disease
Portsmouth Hospitals NHS Trust
 August 7 2019 --
NCT03938610 Recruiting
Knowledge Attitudes Practice
Pamela Hughes|Mike O''Callaghan Military Hospital
 June 1 2019 --
NCT03675308 Active not recruiting
Psoriatic Arthritis
AbbVie
 March 25 2019 Phase 3
NCT03671148 Active not recruiting
Psoriatic Arthritis (PsA)
AbbVie
 March 7 2019 Phase 3
NCT02709486 Completed
Osteoarthritis Hip|Osteoarthritis Knee
Pfizer|Eli Lilly and Company
 March 2 2016 Phase 3

Chemical Information & Solubility

Molecular Weight 286.31 Formula

C14H10N2O3S
CAS No. 448906-42-1 SDF --
Smiles COC(=O)C1=CSC(=N1)C(=O)C2=C[NH]C3=CC=CC=C23
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 57 mg/mL ( (199.08 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 2 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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