Home Cell Cycle HSP (HSP90) inhibitor HSP27 inhibitor J2 For research use only.

HSP27 inhibitor J2

Synonyms: J2

HSP27 inhibitor J2 (J2) is an inhibitor of HSP27, which induces abnormal HSP27 dimers formation and suppresses the generation of HSP27 giant polymers, inhibiting the chaperone role of HSP27 and diminishing its cellular protective function. HSP27 inhibitor J2 (J2) enhances the antiproliferative activity of 17-AAG and increases the sensitivity of cisplatin-induced lung cancer cell growth inhibition.

HSP27 inhibitor J2 Chemical Structure

HSP27 inhibitor J2 Chemical Structure

CAS: 2133499-85-9

Purity & Quality Control

Batch: S340401 DMSO] 26 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 98.61%
98.61

HSP27 inhibitor J2 Related Products

Signaling Pathway

HSP (HSP90) Signaling Pathways

HSP (HSP90) Signaling Pathway

Choose Selective HSP (HSP90) Inhibitors

Biological Activity

Description HSP27 inhibitor J2 (J2) is an inhibitor of HSP27, which induces abnormal HSP27 dimers formation and suppresses the generation of HSP27 giant polymers, inhibiting the chaperone role of HSP27 and diminishing its cellular protective function. HSP27 inhibitor J2 (J2) enhances the antiproliferative activity of 17-AAG and increases the sensitivity of cisplatin-induced lung cancer cell growth inhibition.

Chemical Information & Solubility

Molecular Weight 264.30 Formula

C13H12O4S
CAS No. 2133499-85-9 SDF Download HSP27 inhibitor J2 SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 26 mg/mL ( (98.37 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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