Home Cell Cycle Aurora Kinase inhibitor - CaMK inhibitor - ROCK inhibitor - PKA inhibitor - PKC inhibitor - PKG inhibitor H-1152 dihydrochloride For research use only.

H-1152 dihydrochloride

Synonyms: H-1152 2HCl

H-1152 dihydrochloride (2HCl) is a membrane-permeable and selective inhibitor of Rho-associated protein kinase (ROCK). H-1152 inhibits ROCK2, PKA, PKC, PKG, AuroraA and CaMK2 with IC50 of 0.0120 μM, 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively.

H-1152 dihydrochloride Chemical Structure

H-1152 dihydrochloride Chemical Structure

CAS No. 871543-07-6

Purity & Quality Control

H-1152 dihydrochloride Related Products

Signaling Pathway

Aurora Kinase Signaling Pathways

Aurora Kinase Signaling Pathway

Biological Activity

Description H-1152 dihydrochloride (2HCl) is a membrane-permeable and selective inhibitor of Rho-associated protein kinase (ROCK). H-1152 inhibits ROCK2, PKA, PKC, PKG, AuroraA and CaMK2 with IC50 of 0.0120 μM, 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively.
Targets
ROCK2 [1]
(Cell-free assay)		 CaMK2 [1]
(Cell-free assay)		 PKG [1]
(Cell-free assay)		 Aurora A [1]
(Cell-free assay)		 PKA [1]
(Cell-free assay)		 Click to View More Targets
0.0120 μM 0.180 μM 0.360 μM 0.745 μM 3.03 μM

Chemical Information & Solubility

Molecular Weight 392.34 Formula

C16H23Cl2N3O2S
CAS No. 871543-07-6 SDF --
Smiles Cl.Cl.CC1CNCCCN1[S](=O)(=O)C2=CC=CC3=C2C(=CN=C3)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 78 mg/mL ( (198.8 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 78 mg/mL

Ethanol : 78 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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