Gefurulimab (Anti-C5 & Serum Albumin)

Synonyms: ALXN1720

Catalog No.A4022 Purity:≥99%

Gefurulimab is a humanized bispecific VHH antibody targeting both terminal complement protein C5 and albumin, with potential anti-inflammatory and immunomodulatory effects. It inhibits the terminal complement pathway by blocking the cleavage of C5 into C5a and C5b, reducing complement-mediated inflammation and cell lysis. By binding to albumin, gefurulimab increases its half-life, offering a potent and selective inhibition of terminal complement activity, including in the rare R885H C5 polymorphism. MW: 28.99 KD.

Purity & Quality Control

≥99

Choose Selective CD markers Inhibitors

Name	Citation	CD38	CD45	CD39	CD88	CD73	Others
RBN013209	0	++
MK-0159	0	+++
CD38 inhibitor 1 (compound 78c)	5	+++
AB680	0					++++
NQ301	1		+				TXA2 receptor
SodiuM Metatungstate	3			++
PMX-53				✔
LY-3475070					✔

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Biological Activity

Description	Gefurulimab is a humanized bispecific VHH antibody targeting both terminal complement protein C5 and albumin, with potential anti-inflammatory and immunomodulatory effects. It inhibits the terminal complement pathway by blocking the cleavage of C5 into C5a and C5b, reducing complement-mediated inflammation and cell lysis. By binding to albumin, gefurulimab increases its half-life, offering a potent and selective inhibition of terminal complement activity, including in the rare R885H C5 polymorphism. MW: 28.99 KD.

Description

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	2456407-94-4
Source	CHO
Storage (From the date of receipt)	-80℃

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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