Home Transmembrane Transporters CD markers inhibitor CD38 inhibitor 1 (compound 78c) For research use only.

CD38 inhibitor 1 (compound 78c)

Synonyms: CD38-IN-78c, MDK-7553

CD38 inhibitor 1 (compound 78c, CD38-IN-78c, MDK-7553) is a potent inhibitor of CD38 with IC50 of 7.3 nM and 1.9 nM for human CD38 and mouse CD38, respetively.

CD38 inhibitor 1 (compound 78c) Chemical Structure

CD38 inhibitor 1 (compound 78c) Chemical Structure

CAS No. 1700637-55-3

Purity & Quality Control

Products often used together with CD38 inhibitor 1 (compound 78c)

Quercetin

CD38 inhibitor 1 and Quercetin use decreases lipopolysaccharides (LPS), inflammation, and CD38 levels and helps to prevent aging and metabolic disorders.

Poljsak B, et al. Int J Mol Sci. 2023 Feb 3;24(3):2959.

Apigenin

CD38 inhibitor 1 and Apigenin enhance NAD+ levels and SIRT1 activity by inhibiting CD38.

Connell NJ, et al. Diabetologia. 2019 Jun;62(6):888-899.

Tectochrysin

Tectochrysin has high binding affinity for CD38, similar to the endogenous inhibitor of CD38 CD38 inhibitor 1.

Zeng P, et al. Front Aging Neurosci. 2022 Nov 30;14:1013891.

Chrysin

Chrysin has high binding affinity for CD38, similar to the endogenous inhibitor of CD38 CD38 inhibitor 1 which was revealed by molecular docking.

Zeng P, et al. Front Aging Neurosci. 2022 Nov 30;14:1013891.

CD38 inhibitor 1 (compound 78c) Related Products

Biological Activity

Description CD38 inhibitor 1 (compound 78c, CD38-IN-78c, MDK-7553) is a potent inhibitor of CD38 with IC50 of 7.3 nM and 1.9 nM for human CD38 and mouse CD38, respetively.
Targets
mCD38 [1]
(Cell-free assay)		 hCD38 [1]
(Cell-free assay)
1.9 nM 7.3 nM
In vitro
In vitro

CD38 inhibitor 1 (compound 78c) increases NAD+ levels, resulting in activation of pro-longevity and health span-related factors including sirtuins, AMPK, and PARPs.[2]
Cell Research Cell lines HEK293T, MEFs, A549, Jurkat T and AML12 cells
Concentrations 0.5 μM, 0.2 - 0.5 μM
Incubation Time 16 h, 24 h
Method

To test the reversibility of the CD38i, A549 cells were treated with vehicle or 0.5 μM 78c for 16 hours. Then, cells were washed and incubated with (78c) or without (78c+release) 78c for another 8 hours.
In Vivo
In vivo

CD38 inhibitor 1 (compound 78c) is found to not only be a very potent inhibitor, but also had suitable physiochemical properties to serve as a robust tool for in vivo studies. In addition, CD38 inhibitor 1 (compound 78c) is able to elevate NAD in both liver and gastrocnemius tissue when dosed orally in a DIO mouse.[1]
Animal Research Animal Models DIO C57Bl6 mice
Dosages 30 mg/kg, 2 mg/kg
Administration Oral gavage, IV

Chemical Information & Solubility

Molecular Weight 413.53 Formula

C22H27N3O3S
CAS No. 1700637-55-3 SDF --
Smiles CN1C2=C(C=C(C=C2)C3=CN=CS3)C(=CC1=O)NC4CCC(CC4)OCCOC
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 42 mg/mL ( (101.56 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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