Home Proteases Secretase inhibitor Fosciclopirox For research use only.

Fosciclopirox

Synonyms: CPX-POM

Fosciclopirox(CPX-POM) selectively delivers the active metabolite, Ciclopirox (CPX) that targets γ-secretase complex (Presenilin 1 and Nicastrin)2. It is used in the treatment of urothelial cancer and a number of solid and hematologic malignancies.

Fosciclopirox Chemical Structure

Fosciclopirox Chemical Structure

CAS No. 1380539-06-9

Purity & Quality Control

Batch: E046501 DMSO]63 mg/mL]false]Ethanol]63 mg/mL]false]Water]Insoluble]false Purity: 99.91%
99.91

Fosciclopirox Related Products

Biological Activity

Description Fosciclopirox(CPX-POM) selectively delivers the active metabolite, Ciclopirox (CPX) that targets γ-secretase complex (Presenilin 1 and Nicastrin)2. It is used in the treatment of urothelial cancer and a number of solid and hematologic malignancies.
Targets
γ-secretase [1]
4 μM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04525131 Completed
Bladder Cancer
CicloMed LLC
 November 25 2020 Phase 2
NCT04608045 Completed
Advanced Solid Tumor
CicloMed LLC
 May 19 2019 Phase 1

Chemical Information & Solubility

Molecular Weight 317.27 Formula

C₁₃H₂₀NO₆P
CAS No. 1380539-06-9 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 63 mg/mL ( (198.56 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 63 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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