Ficlatuzumab (Anti-HGF / SF)

Catalog No.A2661 Purity:≥99%

Ficlatuzumab (Anti-HGF / SF) is a monoclonal antibody (McAb) targeting human hepatocyte growth factor (HGF). It inhibits c-Met receptor-mediated cancer cell proliferation, migration, and invasion and can be used to treat head and neck squamous cell carcinoma (HNSCC). MW :150 KD.

Purity & Quality Control

≥99

Choose Selective c-Met Inhibitors

Name	Citation	c-Met	Others
Foretinib	93	++++	KDR,Tie-2,VEGFR3/FLT4
PHA-665752	93	++	RON,Flk1
SU11274	63	++
SGX-523	133	+++
BMS-777607	57	+++	Axl,RON,Tyro3
Tivantinib	49	+
JNJ-38877605	52	+++
PF-04217903	22	++
MGCD-265 analog	12	++++	RON,VEGFR1,VEGFR2
BMS-754807	51	++	Insulin Receptor,IGF-1R,TrkB
BMS-794833	1	+++	VEGFR2
AMG-208	0	++
MK-2461	4	++++	c-Met (Y1235D),c-Met (Y1230C),c-Met (N1100)
Golvatinib (E7050)	8	+	VEGFR2
AMG-458	0	++++
Tepotinib	19	+++
NVP-BVU972	1	+
XL092	0	+	VEGFR2,AXL,MER
UNC2025	7	+	FLT3,Mer,Axl
Ningetinib	0	++	Axl,VEGFR2
Elzovantinib (TPX-0022)	0	++++	SRC,CSF1R
AMG-1	0	+++	RON
Pamufetinib (TAS-115)	0	+	recombinant VEGFR2
JNJ-38877618(OMO-1)	0	+++	MET (M1268T)
Altiratinib	2	+++	MET Y1230C,TrkA,TrkC
SAR125844	0	++++	MET Y1235D,MET M1250T,TRKA/NTRK1
Glumetinib	1	++++
Savolitinib (AZD6094)	16	++	p-Met
CEP-40783 (RXDX-106)	6	+	Axl,Tyro3,MER
S49076	1	++++	Mer,Axl,FGFR3
Merestinib (LY2801653)	10	+++	DDR1,AXL,FLT3
AMG 337	2	++++
NPS-1034	3	+	Axl
Amuvatinib (MP-470)	✔	c-RET,RAD51,c-Kit (D816H)
Glesatinib	✔	SMO
Terevalefim	✔
Licochalcone D	✔	Caspase,EGFR,JAK2
BAY-474	✔
Bozitinib	✔
Pulsatilla saponin D	✔
Sodium L-ascorbyl-2-phosphate	✔
Norcantharidin	✔	EGFR

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Biological Activity

Description	Ficlatuzumab (Anti-HGF / SF) is a monoclonal antibody (McAb) targeting human hepatocyte growth factor (HGF). It inhibits c-Met receptor-mediated cancer cell proliferation, migration, and invasion and can be used to treat head and neck squamous cell carcinoma (HNSCC). MW :150 KD.

References
[1] Kumar D, et al. JAMA Otolaryngol Head Neck Surg. 2015 Dec;141(12):1133-9.

References

[1] Kumar D, et al. JAMA Otolaryngol Head Neck Surg. 2015 Dec;141(12):1133-9.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1174900-84-5
Molecular Weight	150
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100mMPro-Ac,20mMArg-Ac，pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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