Home Protein Tyrosine Kinase c-Met chemical Terevalefim For research use only.

Terevalefim

Synonyms: ANG-3777

Terevalefim (ANG-3777), a small molecule hepatocyte growth factor (HGF) mimetic, induces c-MET dimerization and phosphorylation, reducing apoptosis and increasing cellular proliferation.

Terevalefim Chemical Structure

Terevalefim Chemical Structure

CAS No. 1070881-42-3

Purity & Quality Control

Batch: E265501 DMSO]35 mg/mL]false]Ethanol]35 mg/mL]false]Water]Insoluble]false Purity: 99.78%
99.78

Terevalefim Related Products

Signaling Pathway

c-Met Signaling Pathways

c-Met Signaling Pathway

Biological Activity

Description Terevalefim (ANG-3777), a small molecule hepatocyte growth factor (HGF) mimetic, induces c-MET dimerization and phosphorylation, reducing apoptosis and increasing cellular proliferation.
Targets
c-MET [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04958187 Unknown status
Hemodialysis
Angion Biomedica Corp|Nucleus Network Ltd
 July 2021 Phase 1
NCT04931524 Unknown status
Healthy
Angion Biomedica Corp|Quotient Sciences
 May 21 2021 Phase 1

Chemical Information & Solubility

Molecular Weight 176.24 Formula

C9H8N2S
CAS No. 1070881-42-3 SDF --
Smiles [NH]1C=CC(=N1)\C=C\C2=CC=CS2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 35 mg/mL ( (198.59 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 35 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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