Home Metabolism Retinoid Receptor inhibitor Fenretinide For research use only.

Fenretinide

Synonyms: NSC 374551, 4-hydroxy(phenyl)retinamide, 4-HPR, MK-4016

Fenretinide is a synthetic derivative of retinoic acid that has a broad-spectrum of cytotoxic activity against primary tumor cells, cell lines, and/or xenografts of various cancers (including neuroblastoma). Fenretinide (4-hydroxy(phenyl)retinamide; 4-HPR) is a synthetic derivative of retinoic acid, fenretinide can bind to retinoic acid receptor (RAR) and retinoid X receptor (RXR) at concentrations necessary to induce cell death.

Fenretinide Chemical Structure

Fenretinide Chemical Structure

CAS No. 65646-68-6

Purity & Quality Control

Fenretinide Related Products

Biological Activity

Description Fenretinide is a synthetic derivative of retinoic acid that has a broad-spectrum of cytotoxic activity against primary tumor cells, cell lines, and/or xenografts of various cancers (including neuroblastoma). Fenretinide (4-hydroxy(phenyl)retinamide; 4-HPR) is a synthetic derivative of retinoic acid, fenretinide can bind to retinoic acid receptor (RAR) and retinoid X receptor (RXR) at concentrations necessary to induce cell death.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04234048 Recruiting
T-cell Lymphoma|Cutaneous/Peripheral T-Cell Lymphoma|Peripheral T-cell Lymphoma|Peripheral T-Cell Lymphoma Not Classified|Primary Cutaneous T-cell Lymphoma|Cutaneous T-Cell Lymphoma Unspecified|Cutaneous T-cell Lymphoma|Follicular T-Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Sézary''s Disease|Mycosis Fungoides
SciTech Development LLC
 December 18 2023 Phase 1
NCT06181760 Completed
Safety and Tolerability
Island Pharmaceuticals|Beyond Drug Development
 November 22 2023 Phase 1
NCT01553071 Terminated
Solid Tumor
South Plains Oncology Consortium
 November 2016 Phase 1
NCT02141958 Completed
Cystic Fibrosis
Elias Matouk|McGill University Health Centre/Research Institute of the McGill University Health Centre
 April 2014 Phase 1
NCT01535157 Terminated
Ovarian Cancer|Cancer of Ovary|Cancer of the Ovary|Ovary Neoplasms|Primary Peritoneal Carcinoma
South Plains Oncology Consortium
 February 2012 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 391.55 Formula

C26H33NO2
CAS No. 65646-68-6 SDF --
Smiles CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)NC2=CC=C(C=C2)O)C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 78 mg/mL ( (199.2 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 25 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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