Home Metabolism phosphatase inhibitor - Apoptosis related activator - ROS activator (E/Z)-BCI For research use only.

(E/Z)-BCI

Synonyms: BCI, NSC 150117

(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.

(E/Z)-BCI Chemical Structure

(E/Z)-BCI Chemical Structure

CAS No. 15982-84-0

Purity & Quality Control

Batch: S005601 DMSO]63 mg/mL]false]Ethanol]20 mg/mL]false]Water]Insoluble]false Purity: 99.89%
99.89

(E/Z)-BCI Related Products

Biological Activity

Description (E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.
Targets
ROS [1] DUSP1 [1]
(Cell-free assay)		 DUSP6 [1]
(Cell-free assay)
8.0 μM(EC50) 13.3 μM(EC50)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05470478 Not yet recruiting
Spinal Cord Injury|Amyotrophic Lateral Sclerosis|Brain Stem Infarctions|Locked-in Syndrome|Muscular Dystrophy
VA Office of Research and Development
 September 1 2024 Not Applicable
NCT06231628 Not yet recruiting
Imaging Guided|Percutaneous Cementoplasty|Pelvic Bone Metstasis
Assiut University
 February 2024 Not Applicable

Chemical Information & Solubility

Molecular Weight 317.42 Formula

C22H23NO
CAS No. 15982-84-0 SDF --
Smiles C1CCC(CC1)NC2C3=CC=CC=C3C(=O)C2=CC4=CC=CC=C4
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 63 mg/mL ( (198.47 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 20 mg/mL

Water : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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