Home Transmembrane Transporters Potassium Channel inhibitor - Sodium Channel inhibitor - Calcium Channel inhibitor Dronedarone HCl For research use only.

Dronedarone HCl

Synonyms: SR33589

Dronedarone HCl (SR33589) is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).

Dronedarone HCl Chemical Structure

Dronedarone HCl Chemical Structure

CAS No. 141625-93-6

Purity & Quality Control

Batch: S211401 DMSO]80 mg/mL]false]Ethanol]40 mg/mL]false]Water]Insoluble]false Purity: 99.98%
99.98

Dronedarone HCl Related Products

Signaling Pathway

Potassium Channel Signaling Pathways

Potassium Channel Signaling Pathway

Biological Activity

Description Dronedarone HCl (SR33589) is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).
Targets
Potassium channel [1] Sodium channel [1] Calcium channel [1]
In vitro
In vitro Dronedarone reduces the incidence of early and delayed after depolarizations evoked by 1 mM Dofetilide and 0.2 mM Strophantidine in Purkinje fibres. Dronedarone (10 mM) markedly reduces the L-type calcium current (76.5%) and the rapid component of the delayed rectifier potassium current (97%) in ventricular myocytes. [1] Dronedarone inhibits the activity of I(K(ACh)) channels recorded from cell-attached patches by reducing the channel open probability (from 0.56 to 0.11) without modification of the single-channel conductance in single cells isolated from sinoatrial node (SAN) tissue of rabbit hearts. [2] Dronedarone exhibits a state-dependent inhibition of the fast Na(+) channel current with an IC50 of 0.7 μM in guinea pig ventricular myocytes, when the holding potential (V (hold)) is -80 mV. Dronedarone blocks Ca(2+) currents elicited by rectangular pulses at V (hold) = -40 mV with IC50 value of 0.4 μM, whereas at V (hold) = -80 mV, Dronedarone (10 μM) blocks only 20 % of the current. [3]
In Vivo
In vivo Dronedarone increases action potential duration in normal hearts of rats. Dronedarone reduces the late sustained K(+) current, I(K) (or Isus) by 69%. Dronedarone induces only a tonic block of I(K). Dronedarone induces a weak increase in the fast transient outward current, I(to), in rats after myocardial infarction. [4]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01430806 Unknown status
ICD|ICD SHOCKS|DRONEDARONE
Rabin Medical Center
 October 2011 Not Applicable
NCT01266681 Unknown status
Atrial Fibrillation
Eastbourne General Hospital
 March 2011 Not Applicable
NCT01199081 Completed
Atrial Fibrillation
Sanofi
 October 2010 Phase 4
NCT01213368 Completed
Atrial Fibrillation
Sanofi
 September 2010 Phase 2
NCT01140581 Completed
Atrial Fibrillation
Sanofi
 September 2010 Phase 4
NCT01070667 Unknown status
Paroxysmal Atrial Fibrillation
Eastbourne General Hospital
 March 2010 Phase 4

Chemical Information & Solubility

Molecular Weight 593.22 Formula

C31H44N2O5S.HCl
CAS No. 141625-93-6 SDF Download Dronedarone HCl SDF
Smiles CCCCC1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C)C(=O)C3=CC=C(C=C3)OCCCN(CCCC)CCCC.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 80 mg/mL ( (134.85 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 40 mg/mL

Water : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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