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Doxorubicin
Synonyms: Adriamycin,Hydroxydaunorubicin
Adriamycin (Doxorubicin, Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent, inhibits topoisomerase II with an IC50 of 2.67 μM, thus stopping DNA replication, and induces apoptosis, also inhibits human DNA topoisomerase I with an IC50 of 0.8 μM.
Doxorubicin Chemical Structure
CAS No. 23214-92-8
Purity & Quality Control
Batch:
Purity:
99.71%
99.71
Doxorubicin Related Products
| Related Targets | Topo I Topo II Topo IV | Click to Expand |
|---|---|---|
| Related Products | Betulinic acid (S)-10-Hydroxycamptothecin Beta-Lapachone Amonafide Voreloxin (SNS-595) hydrochloride Ellagic acid Genz-644282 Hydroxy Camptothecine Rubitecan | Click to Expand |
| Related Compound Libraries | FDA-approved Drug Library Natural Product Library Apoptosis Compound Library DNA Damage/DNA Repair compound Library Cell Cycle compound library | Click to Expand |
Signaling Pathway
Biological Activity
| Description | Adriamycin (Doxorubicin, Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent, inhibits topoisomerase II with an IC50 of 2.67 μM, thus stopping DNA replication, and induces apoptosis, also inhibits human DNA topoisomerase I with an IC50 of 0.8 μM. | ||||
|---|---|---|---|---|---|
| Targets |
|
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT06186700 | Active not recruiting | Breast Cancer Female |
Mansoura University |
December 25 2023 | Phase 2 |
| NCT05567601 | Not yet recruiting | Ovarian Cancer|AIDS-related Kaposi Sarcoma|Multiple Myeloma|Metastatic Breast Cancer |
Baxter Healthcare Corporation |
November 30 2023 | Phase 1 |
| NCT06088290 | Recruiting | Leiomyosarcoma |
PharmaMar |
September 21 2023 | Phase 2|Phase 3 |
| NCT04925089 | Recruiting | Leiomyosarcoma |
University of Michigan Rogel Cancer Center|National Cancer Institute (NCI) |
April 26 2023 | -- |
Chemical Information & Solubility
| Molecular Weight | 543.52 | Formula | C27H29NO11 |
| CAS No. | 23214-92-8 | SDF | -- |
| Smiles | COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(=O)CO)O)C(=O)C2=CC=C1 | ||
| Storage (From the date of receipt) | 3 years -20°C powder | ||
|
In vitro |
DMSO : 100 mg/mL ( (183.98 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.) Water : 100 mg/mL Ethanol : Insoluble |
Molecular Weight Calculator |
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In vivo Add solvents to the product individually and in order. |
In vivo Formulation Calculator |
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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