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Technical Data
| Formula | C27H29NO11 |
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| Molecular Weight | 543.52 | CAS No. | 23214-92-8 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (183.98 mM) | |
| Water | 100 mg/mL (183.98 mM) | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Adriamycin (Doxorubicin, Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent, inhibits topoisomerase II with an IC50 of 2.67 μM, thus stopping DNA replication, and induces apoptosis, also inhibits human DNA topoisomerase I with an IC50 of 0.8 μM. | ||||
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Protocol (from reference)
References
Selleck's Doxorubicin has been cited by 131 publications
| HDAC activity is dispensable for repression of cell-cycle genes by DREAM and E2F:RB complexes [ Nat Commun, 2024, 15(1):4450] | PubMed: 38789411 |
| Detection of senescence using machine learning algorithms based on nuclear features [ Nat Commun, 2024, 15(1):1041] | PubMed: 38310113 |
| FUNDC1 alleviates doxorubicin-induced cardiotoxicity by restoring mitochondrial-endoplasmic reticulum contacts and blocked autophagic flux [ Theranostics, 2024, 14(9):3719-3738] | PubMed: 38948070 |
| FTO ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via P53-P21/Nrf2 activation in a HuR-dependent m6A manner [ Redox Biol, 2024, 70:103067] | PubMed: 38316068 |
| DPP9 regulates NQO1 and ROS to promote resistance to chemotherapy in liver cancer cells [ Redox Biol, 2024, 75:103292] | PubMed: 39094401 |
| Tumor phagocytosis-driven STING activation invigorates antitumor immunity and reprograms the tumor micro-environment [ J Control Release, 2024, 373:55-69] | PubMed: 38971428 |
| A versatile engineered extracellular vesicle platform simultaneously targeting and eliminating senescent stromal cells and tumor cells to promote tumor regression [ J Nanobiotechnology, 2024, 22(1):105] | PubMed: 38468249 |
| Inhibiting autophagy enhanced mitotic catastrophe-mediated anticancer immune responses by regulating the cGAS-STING pathway [ Cancer Lett, 2024, 586:216695] | PubMed: 38325769 |
| Induction of IFIT1/IFIT3 and inhibition of Bcl-2 orchestrate the treatment of myeloma and leukemia via pyroptosis [ Cancer Lett, 2024, 588:216797] | PubMed: 38462032 |
| Intracellular cartilage oligomeric matrix protein augments breast cancer resistance to chemotherapy [ Cell Death Dis, 2024, 15(7):480] | PubMed: 38965233 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.