Home Neuronal Signaling COX inhibitor Diclofenac Diethylamine For research use only.

Diclofenac Diethylamine

Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. Diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.

Diclofenac Diethylamine Chemical Structure

Diclofenac Diethylamine Chemical Structure

CAS No. 78213-16-8

Purity & Quality Control

Batch: S306301 DMSO]74 mg/mL]false]Ethanol]74 mg/mL]false]Water]Insoluble]false Purity: 99.98%
99.98

Diclofenac Diethylamine Related Products

Signaling Pathway

COX Signaling Pathways

COX Signaling Pathway

Biological Activity

Description Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. Diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.
In vitro
In vitro The primary mechanism of diclofenac diethylamine responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac diethylamine has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06053411 Not yet recruiting
Interaction
Washington State University
 January 1 2024 Early Phase 1
NCT06146491 Recruiting
Pain Postoperative
B.P. Koirala Institute of Health Sciences
 August 10 2023 Phase 4
NCT05968482 Active not recruiting
Healthy
Amzell
 July 11 2023 Phase 1
NCT05752526 Active not recruiting
Dysmenorrhea Primary
Daré Bioscience Inc.
 May 19 2023 Phase 1

Chemical Information & Solubility

Molecular Weight 369.29 Formula

C14H11Cl2NO2.C4H11N
CAS No. 78213-16-8 SDF Download Diclofenac Diethylamine SDF
Smiles CCNCC.C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 74 mg/mL ( (200.38 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 74 mg/mL

Water : Insoluble


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