Home Epigenetics Histone Demethylase inhibitor - JMJD inhibitor Daminozide For research use only.

Daminozide

Synonyms: Aminozide, DMASA, DIMG, B 995, Alar, Kylar, B-NINE, SADH

Daminozide (Aminozide, DMASA, DIMG, B 995, Alar, Kylar, B-NINE, SADH) is a plant growth regulator that selectively inhibits human KDM2/7 histone demethylases, with IC50 of 0.55 μM for PHF8 (KDM7B), 1.5 μM for KDM2A, and 2.1 μM for KIAA1718 (KDM7A). It shows over 100-fold selectivity for the KDM2/7 subfamily compared to other histone demethylase subfamilies, with significantly weaker activity against enzymes such as KDM3A with IC50 of 127 μM.

Daminozide Chemical Structure

Daminozide Chemical Structure

CAS No. 1596-84-5

Purity & Quality Control

Batch: S480001 DMSO]32 mg/mL]false]]]false]]]false Purity: 98%
98

Daminozide Related Products

Signaling Pathway

Histone Demethylase Signaling Pathways

Histone Demethylase Signaling Pathway

Biological Activity

Description Daminozide (Aminozide, DMASA, DIMG, B 995, Alar, Kylar, B-NINE, SADH) is a plant growth regulator that selectively inhibits human KDM2/7 histone demethylases, with IC50 of 0.55 μM for PHF8 (KDM7B), 1.5 μM for KDM2A, and 2.1 μM for KIAA1718 (KDM7A). It shows over 100-fold selectivity for the KDM2/7 subfamily compared to other histone demethylase subfamilies, with significantly weaker activity against enzymes such as KDM3A with IC50 of 127 μM.
Targets
PHF8 [1]
(Cell-free assay)		 KDM2A [1]
(Cell-free assay)
0.55 μM 1.5 μM
In Vivo
In vivo

In vivo, daminozide is proposed to inhibit 2OG oxygenases involved in gibberellin, and possibly ethylene, biosynthesis in plants[1].

Chemical Information & Solubility

Molecular Weight 160.17 Formula

C6H12N2O3
CAS No. 1596-84-5 SDF Download Daminozide SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 32 mg/mL ( (199.78 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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