Home Epigenetics Histone Demethylase inhibitor - JMJD inhibitor Daminozide For research use only.

Daminozide

Synonyms: Aminozide, DMASA, DIMG, B 995, Alar, Kylar, B-NINE, SADH

Daminozide (Aminozide, DMASA, DIMG, B 995, Alar, Kylar, B-NINE, SADH), a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily with IC50 of 1.5±0.7 μM for KDM2A. It is at least 100-fold selective as an inhibitor of the KDM2/7 subfamily over the other demethylase subfamily members tested, with IC50s of 2 μM or less against KDM2A, PHF8, and KIAA1718 and IC50s of 127 μM for KDM3A or greater (mM range) against other demethylases.

Daminozide Chemical Structure

Daminozide Chemical Structure

CAS No. 1596-84-5

Purity & Quality Control

Batch: S480001 DMSO]32 mg/mL]false]]]false]]]false Purity: 98%
98

Daminozide Related Products

Signaling Pathway

Histone Demethylase Signaling Pathways

Histone Demethylase Signaling Pathway

Biological Activity

Description Daminozide (Aminozide, DMASA, DIMG, B 995, Alar, Kylar, B-NINE, SADH), a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily with IC50 of 1.5±0.7 μM for KDM2A. It is at least 100-fold selective as an inhibitor of the KDM2/7 subfamily over the other demethylase subfamily members tested, with IC50s of 2 μM or less against KDM2A, PHF8, and KIAA1718 and IC50s of 127 μM for KDM3A or greater (mM range) against other demethylases.
Targets
PHF8 [1]
(Cell-free assay)		 KDM2A [1]
(Cell-free assay)
0.55 μM 1.5 μM
In Vivo
In vivo In vivo, daminozide is proposed to inhibit 2OG oxygenases involved in gibberellin, and possibly ethylene, biosynthesis in plants[1].

Chemical Information & Solubility

Molecular Weight 160.17 Formula

C6H12N2O3
CAS No. 1596-84-5 SDF Download Daminozide SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 32 mg/mL ( (199.78 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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