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JMJD

Isoform-selective Products

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JMJD Products

All (9)
JMJD Inhibitors (9)
New JMJD Products

Catalog No.	Product Name	Information	Product Use Citations	Product Validations
S7070	GSK J4 HCl	GSK J4 HCl is a cell permeable prodrug of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM in a cell-free assay and inactive against a panel of demethylases of the JMJ family.	Nat Cell Biol, 2024, 26(7):1165-1175 J Clin Invest, 2024, 134(1)e163964 Clin Epigenetics, 2024, 16(1):51
S8287	CPI-455 HCl	CPI-455 HCl is a specific KDM5 inhibitor with a half-maximal inhibitory concentration (IC50) of 10 ± 1 nM for full-length KDM5A in enzymatic assays, elevating global levels of H3K4 trimethylation (H3K4me3) and decreased the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents.	Nature, 2023, 622(7983):619-626 Nature, 2023, 622(7983):619-626 Cancer Cell, 2023, 41(6):1118-1133.e12
S7281	JIB-04	JIB-04 (NSC 693627) is a pan-selective Jumonji histone demethylase inhibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D in cell-free assays, respectively. JIB‑04 also induces cell apoptosis.	Cancer Cell, 2023, 41(6):1118-1133.e12 mBio, 2022, 13(1):e0337721 iScience, 2022, 25(9):104978
S7296	ML324	ML324 is a selective inhibitor of jumonji histone demethylase (JMJD2) with IC50 of 920 nM.	Cancer Cell, 2023, 41(6):1118-1133.e12 EBioMedicine, 2023, 92:104602 Viruses, 2023, 15(1)163
S7234	IOX1	IOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. IOX1 is an inhibitor of ALKBH5.	Front Immunol, 2024, 15:1308978 Nat Commun, 2023, 14(1):1161 Nat Commun, 2022, 13(1):1172
S7581	GSK J1	GSK-J1 is a highly potent inhibitor of H3K27 histone demethylase JMJD3 (KDM6B) and UTX (KDM6A) with IC50 of 60 nM in cell-free assays for JMJD3 (KDM6B) , respectively, >10-fold selectivity over other tested demethylases, with IC50 of 0.95μM and 1.76μM towards JARID1B/C.	Cell Rep Med, 2023, 4(5):101026 Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7 J Biol Chem, 2022, S0021-9258(22)00457-4
S8601	CP2	CP2 is a cyclic peptide that inhibits the JmjC histone demethylases KDM4 with IC50 values of 42 nM and 29 nM for KDM4A and KDM4C, respectively.	Oxid Med Cell Longev, 2022, 2022:2405943 Front Cell Dev Biol, 2021, 9:697614 Exp Cell Res, 2021, S0014-4827(21)00315-3
E1315	iJMJD6	iJMJD6(WL12) is an inhibitor of arginine demethylase JMJD6 with an IC50 value of 0.22 μM.
S0201	Z-JIB-04 (NSC 693627)	Z-JIB-04 (NSC 693627, JIB-04 Z-isomer) is an isomer of JIB-04. JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50 of 230 nM, 340 nM, 855 nM, 445 nM, 435 nM, 1100 nM and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively.
S7070	GSK J4 HCl	GSK J4 HCl is a cell permeable prodrug of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM in a cell-free assay and inactive against a panel of demethylases of the JMJ family.	Nat Cell Biol, 2024, 26(7):1165-1175 J Clin Invest, 2024, 134(1)e163964 Clin Epigenetics, 2024, 16(1):51
S8287	CPI-455 HCl	CPI-455 HCl is a specific KDM5 inhibitor with a half-maximal inhibitory concentration (IC50) of 10 ± 1 nM for full-length KDM5A in enzymatic assays, elevating global levels of H3K4 trimethylation (H3K4me3) and decreased the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents.	Nature, 2023, 622(7983):619-626 Nature, 2023, 622(7983):619-626 Cancer Cell, 2023, 41(6):1118-1133.e12
S7281	JIB-04	JIB-04 (NSC 693627) is a pan-selective Jumonji histone demethylase inhibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D in cell-free assays, respectively. JIB‑04 also induces cell apoptosis.	Cancer Cell, 2023, 41(6):1118-1133.e12 mBio, 2022, 13(1):e0337721 iScience, 2022, 25(9):104978
S7296	ML324	ML324 is a selective inhibitor of jumonji histone demethylase (JMJD2) with IC50 of 920 nM.	Cancer Cell, 2023, 41(6):1118-1133.e12 EBioMedicine, 2023, 92:104602 Viruses, 2023, 15(1)163
S7234	IOX1	IOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. IOX1 is an inhibitor of ALKBH5.	Front Immunol, 2024, 15:1308978 Nat Commun, 2023, 14(1):1161 Nat Commun, 2022, 13(1):1172
S7581	GSK J1	GSK-J1 is a highly potent inhibitor of H3K27 histone demethylase JMJD3 (KDM6B) and UTX (KDM6A) with IC50 of 60 nM in cell-free assays for JMJD3 (KDM6B) , respectively, >10-fold selectivity over other tested demethylases, with IC50 of 0.95μM and 1.76μM towards JARID1B/C.	Cell Rep Med, 2023, 4(5):101026 Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7 J Biol Chem, 2022, S0021-9258(22)00457-4
S8601	CP2	CP2 is a cyclic peptide that inhibits the JmjC histone demethylases KDM4 with IC50 values of 42 nM and 29 nM for KDM4A and KDM4C, respectively.	Oxid Med Cell Longev, 2022, 2022:2405943 Front Cell Dev Biol, 2021, 9:697614 Exp Cell Res, 2021, S0014-4827(21)00315-3
E1315	iJMJD6	iJMJD6(WL12) is an inhibitor of arginine demethylase JMJD6 with an IC50 value of 0.22 μM.
S0201	Z-JIB-04 (NSC 693627)	Z-JIB-04 (NSC 693627, JIB-04 Z-isomer) is an isomer of JIB-04. JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50 of 230 nM, 340 nM, 855 nM, 445 nM, 435 nM, 1100 nM and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively.

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