Home Epigenetics Histone Demethylase inhibitor - JMJD inhibitor CP2 For research use only.

CP2

CP2 is a cyclic peptide that inhibits the JmjC histone demethylases KDM4 with IC50 values of 42 nM and 29 nM for KDM4A and KDM4C, respectively.

CP2 Chemical Structure

CP2 Chemical Structure

CAS No. no CAS

Purity & Quality Control

CP2 Related Products

Signaling Pathway

Histone Demethylase Signaling Pathways

Histone Demethylase Signaling Pathway

Biological Activity

Description CP2 is a cyclic peptide that inhibits the JmjC histone demethylases KDM4 with IC50 values of 42 nM and 29 nM for KDM4A and KDM4C, respectively.
Targets
KDM4C [1]
(Cell-free assay)		 KDM4A [1]
(Cell-free assay)
29 nM 42 nM
In vitro
In vitro CP2 uniquely binds in the KDM4A substrate-binding pocket. It binds differently to, but competes with, histone substrates in the active site[1].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01241812 Completed
Knee Osteoarthritis
University of British Columbia|Canadian Arthritis Network
 October 2010 Not Applicable
NCT00261846 Completed
Chronic Myeloid Leukemia
Pfizer
 January 18 2006 Phase 2

Chemical Information & Solubility

Molecular Weight 2010.15 Formula

C92H120N24O26S
CAS No. no CAS SDF Download CP2 SDF
Smiles CC(C)C1NC(=O)C(CC2=CC=C(O)C=C2)NNC(CC(O)=O)C(=O)C(=O)CSCC(NC(=O)C(NC(=O)C(CC3=CC=C(O)C=C3)NC(=O)C(CC4=C[NH]C5=C4C=CC=C5)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC6=C[NH]C7=C6C=CC=C7)NC(=O)CNC(=O)C(CO)NC(=O)C(CCCNC
Storage (From the date of receipt)

In vitro
Batch:

Water : 100 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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