Home Cell Cycle MPS1 inhibitor BOS172722 For research use only.

BOS172722

BOS172722 is a monopolar spindle 1 (MPS1) checkpoint inhibitor with IC50 of 11 nM, Ki of 0.11 nM.

BOS172722 Chemical Structure

BOS172722 Chemical Structure

CAS No. 1578245-44-9

Purity & Quality Control

Batch: S891101 DMSO]Insoluble]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.65%
99.65

BOS172722 Related Products

Biological Activity

Description BOS172722 is a monopolar spindle 1 (MPS1) checkpoint inhibitor with IC50 of 11 nM, Ki of 0.11 nM.
Targets
MPS1 [1]
(Cell-free assay)		 MPS1 [1]
(Cell-free assay)
0.11 nM(Ki) 11 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03328494 Completed
Advanced Nonhaematologic Malignancies
Boston Pharmaceuticals
 October 13 2017 Phase 1

Chemical Information & Solubility

Molecular Weight 446.55 Formula

C24H30N8O
CAS No. 1578245-44-9 SDF --
Smiles CCOC1=C(C=CC(=C1)C2=NN=CN2C)NC3=NC=C4C=C(N=C(C4=N3)NCC(C)(C)C)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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