MPS1

MPS1 Products

All (7)
MPS1 Inhibitors (7)
New MPS1 Products

Catalog No.	Product Name	Information	Product Use Citations
S2731	AZ 3146	AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit.	Research Square, 2024, 10.21203/rs.3.rs-2161438/v1 Nature, 2023, 617(7959):154-161 Nat Commun, 2023, 14(1):6505
S8215	BAY 1217389	BAY 1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1) with IC50 values below 10 nmol/L while showing an excellent selectivity profile.	Nat Commun, 2023, 10.1038/s41467-023-43274-3 Dev Cell, 2023, 58(3):192-210.e11 bioRxiv, 2023, 2023.04.02.535275
S7488	MPI-0479605	MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases.	Mol Biol Cell, 2024, 35(8):br15 Nature, 2022, 604(7904):146-151 J Ovarian Res, 2021, 14(1):128
S8214	Empesertib (BAY1161909)	Empesertib (BAY1161909, Mps1-IN-5), a derivative of triazolopyridine, is an orally bioavailable, selective inhibitor of the serine/threonine monopolar spindle 1 (Mps1) kinase with IC50 of <1 nM. Empesertib has potential antineoplastic activity.	Sci Adv, 2023, 9(3):eadd6982
S8911	BOS172722	BOS172722 is a monopolar spindle 1 (MPS1) checkpoint inhibitor with IC50 of 11 nM, Ki of 0.11 nM.
E1428	Mps1-IN-6 (Compound 9)	Mps1-IN-6 (Compound 9) is a potent Mps1 inhibitor with IC50 of 6.4 nM. It also exhibits antiproliferative and anti-tumor activity in breast cancer cells.
S6768	CC-671	CC-671 is a selectively dual inhibitor of TTK (human protein kinase monopolar spindle 1 [hMps1]) and CDC like kinase 2 (CLK2) with IC50s of 5 nM and 3 nM for TTK and CLK2, respectively.
S2731	AZ 3146	AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit.	Research Square, 2024, 10.21203/rs.3.rs-2161438/v1 Nature, 2023, 617(7959):154-161 Nat Commun, 2023, 14(1):6505
S8215	BAY 1217389	BAY 1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1) with IC50 values below 10 nmol/L while showing an excellent selectivity profile.	Nat Commun, 2023, 10.1038/s41467-023-43274-3 Dev Cell, 2023, 58(3):192-210.e11 bioRxiv, 2023, 2023.04.02.535275
S7488	MPI-0479605	MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases.	Mol Biol Cell, 2024, 35(8):br15 Nature, 2022, 604(7904):146-151 J Ovarian Res, 2021, 14(1):128
S8214	Empesertib (BAY1161909)	Empesertib (BAY1161909, Mps1-IN-5), a derivative of triazolopyridine, is an orally bioavailable, selective inhibitor of the serine/threonine monopolar spindle 1 (Mps1) kinase with IC50 of <1 nM. Empesertib has potential antineoplastic activity.	Sci Adv, 2023, 9(3):eadd6982
S8911	BOS172722	BOS172722 is a monopolar spindle 1 (MPS1) checkpoint inhibitor with IC50 of 11 nM, Ki of 0.11 nM.
E1428	Mps1-IN-6 (Compound 9)	Mps1-IN-6 (Compound 9) is a potent Mps1 inhibitor with IC50 of 6.4 nM. It also exhibits antiproliferative and anti-tumor activity in breast cancer cells.
S6768	CC-671	CC-671 is a selectively dual inhibitor of TTK (human protein kinase monopolar spindle 1 [hMps1]) and CDC like kinase 2 (CLK2) with IC50s of 5 nM and 3 nM for TTK and CLK2, respectively.

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