Bemarituzumab (Anti-FGFR2 / CD332)

Catalog No.A2497 Purity:99%

Bemarituzumab (Anti-FGFR2 / CD332) is a first-in-class, humanized IgG1 monoclonal antibody against FGFR2b (a FGF receptor). Bemarituzumab blocks fibroblast growth factors from binding and activating FGFR2b. Bemarituzumab has the potential for cancer research. MW: 145.24 KD.

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Purity & Quality Control

Batch: Purity: 99% Protein concentration: 5.933mg/ml Endotoxin Level: ＜1EU/mg

Choose Selective FGFR Inhibitors

Name	Citation	FGFR	FGFR1	FGFR2	FGFR3	FGFR4	Others
PD173074	120		++				VEGFR2
Dovitinib (TKI-258)	49		+++		+++		FLT3,c-Kit,VEGFR3/FLT4
Fexagratinib (AZD4547)	135		++++	++++	++++		KDR
Danusertib (PHA-739358)	46		++				Aurora A,Abl,TrkA
Brivanib (BMS-540215)	9		+				VEGFR2,Flk1,VEGFR1
ENMD-2076	8		+	+			FLT3,RET,Aurora A
MK-2461	4		+	++	++		c-Met (M1250T),c-Met (Y1235D),c-Met (Y1230H)
Brivanib Alaninate (BMS-582664)	2		+				VEGFR2,Flk1,VEGFR1
Tyrphostin AG 1296	14	+					PDGFR,c-Kit (Swiss 3T3)
SSR128129E	9		+
R1530	0		++				VEGFR2
FIIN-3	0		+++	++	++	++
Lucitanib (E3810) hydrochloride	1		++	+			VEGFR1,VEGFR3,VEGFR2
Sulfatinib	1		+++				VEGFR3,VEGFR1,CSF1R
ODM-203	0		+++	+++	+++	++	VEGFR3,VEGFR2,VEGFR1
Futibatinib (TAS-120)	14		++++	++++	++++	+++
ASP5878	3		++++	++++	++++	+++
Derazantinib	4		+++	++++	+++	++	RET,DDR2,PDGFRβ
H3B-6527	11					++++
Roblitinib (FGF401)	4					++++
PRN1371	2		++++	++++	+++	++	CSF1R
PD-166866	12		+
Fisogatinib (BLU-554)	8					+++
S49076	1		++	++	+++		Met,Mer,Axl
NSC12	2			+			FGF3,FGF8b,FGF22
ON123300	3		++				CDK4/CyclinD1,RET,CDK6/CyclinD1
SU5402	17		++				VEGFR2,PDGFRβ
BLU9931	18				+	+++
FIIN-2	4		+++	+++	++	++
Dovitinib (TKI258) Lactate monohydrate	30		+++		+++		FLT3,c-Kit,VEGFR3/FLT4
Zoligratinib (Debio-1347)	11		+++	+++	++	+
LY2874455	14		+++	+++	+++	+++	VEGFR2
Ferulic Acid	6		+	+
Lirafugratinib			✔
Masitinib mesylate				✔		FAK,human recombinant c-Kit,LynB
BO-264				✔		TACC3
SKLB 610			✔			PDGFR,VEGFR2
Alofanib (RPT835)			✔
Gambogenic acid	✔					EZH2

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Biological Activity

Description	Bemarituzumab (Anti-FGFR2 / CD332) is a first-in-class, humanized IgG1 monoclonal antibody against FGFR2b (a FGF receptor). Bemarituzumab blocks fibroblast growth factors from binding and activating FGFR2b. Bemarituzumab has the potential for cancer research. MW: 145.24 KD.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1952272-74-0
Molecular Weight	145.24 kDa
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100mMPro-Ac,20mMArg-Ac，pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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