Home Angiogenesis FGFR inhibitor Lirafugratinib For research use only.

Lirafugratinib

Synonyms: RLY-4008

Lirafugratinib (RLY-4008) is an orally active and selective inhibitor of FGFR2.

Lirafugratinib Chemical Structure

Lirafugratinib Chemical Structure

CAS No. 2549174-42-5

Purity & Quality Control

Batch: E143101 DMSO]20 mg/mL]false]Ethanol]2 mg/mL]false]Water]Insoluble]false Purity: 99.01%
99.01

Lirafugratinib Related Products

Signaling Pathway

FGFR Signaling Pathways

FGFR Signaling Pathway

Biological Activity

Description Lirafugratinib (RLY-4008) is an orally active and selective inhibitor of FGFR2.
Targets
FGFR2 [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04526106 Active not recruiting
FGFR2 Amplification|FGFR2 Gene Mutation|FGFR2 Gene Fusion/Rearrangement|FGFR2 Gene Translocation|FGFR2 Gene Activation|Intrahepatic Cholangiocarcinoma|Cholangiocarcinoma|Other Solid Tumors Adult
Relay Therapeutics Inc.
 September 2 2020 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 509.54 Formula

C28H24FN7O2
CAS No. 2549174-42-5 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 20 mg/mL ( (39.25 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 2 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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