Home Neuronal Signaling 5-HT Receptor inhibitor Atomoxetine HCl For research use only.

Atomoxetine HCl

Synonyms: LY 139603 HCl

Atomoxetine (LY 139603) is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.

Atomoxetine HCl Chemical Structure

Atomoxetine HCl Chemical Structure

CAS No. 82248-59-7

Purity & Quality Control

Batch: S317501 DMSO]58 mg/mL]false]Ethanol]37 mg/mL]false]Water]2 mg/mL]false Purity: 99.96%
99.96

Atomoxetine HCl Related Products

Signaling Pathway

5-HT Receptor Signaling Pathways

5-HT Receptor Signaling Pathway

Biological Activity

Description Atomoxetine (LY 139603) is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.
Targets
Norepinephrine (NE) transporter [1] 5-HT [1] DA transporter [1]
5 nM(Ki) 77 nM(Ki) 1451 nM(Ki)
In vitro
In vitro Atomoxetine is a selective norepinephrine reuptake inhibitor with Ki of 5 nM, compared with 77 and 1451 nM for binding to serotonin and dopamine transporters. [1]
In Vivo
In vivo In microdialysis studies, atomoxetine increases extracellular (EX) levels of NE in prefrontal cortex (PFC) 3-fold, but does not alter 5-HTEX levels. Atomoxetine also increases DAEX concentrations in PFC 3-fold, but does not alter DAEX in striatum or nucleus accumbens. Atomoxetine increases Fos by 3.7-fold in PFC, but not in the striatum or nucleus accumbens. [1] Atomoxetine selectively inhibits the presynaptic uptake of norepinephrine in adrenergic neurons in animals, and has activity in animal models of depression. [2][3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03154359 Completed
ADHD
Children''s Mercy Hospital Kansas City|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
 December 12 2017 --
NCT03460210 Recruiting
Obesity Morbid
Norwegian University of Science and Technology|St. Olavs Hospital|Volvat Medisinsk Senter Stokkan|Namsos Hospital|Alesund Hospital
 November 2 2016 --
NCT01522404 Completed
Mild Cognitive Impairment
Emory University|National Institute on Aging (NIA)
 March 2012 Phase 2
NCT01709695 Completed
ADHD|Attention Deficit Hyperactivity Disorder
Icahn School of Medicine at Mount Sinai
 March 2011 Phase 4

Chemical Information & Solubility

Molecular Weight 291.82 Formula

C17H21NO.HCl
CAS No. 82248-59-7 SDF Download Atomoxetine HCl SDF
Smiles CC1=CC=CC=C1OC(CCNC)C2=CC=CC=C2.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 58 mg/mL ( (198.75 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 37 mg/mL

Water : 2 mg/mL


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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