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Amikacin hydrate

Name: Amikacin hydrate
Brand: Selleck Chemicals
SKU: S3122
Rating: 5 (2 reviews)

Synonyms: BAY416651 hydrate

Catalog No.S3122 Purity:99.47%

Amikacin(BAY416651 hydrate) is an aminoglycoside antibiotic used to treat different types of bacterial infections.

Amikacin hydrate Chemical Structure

CAS No. 1257517-67-1

Purity & Quality Control

Antibiotic Titer > 900 u/mg
Cited in Nature Medicine for its top-tier quality
COA
Datasheet
SDS

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Biological Activity

Description	Amikacin(BAY416651 hydrate) is an aminoglycoside antibiotic used to treat different types of bacterial infections.

In vitro
In vitro	Amikacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Amikacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT05555303	Recruiting	Tuberculosis Multidrug-Resistant	Rwanda Biomedical Centre\|Institute of Tropical Medicine\|World Health Organization	March 1 2023	Phase 2
NCT05689450	Completed	Febrile Neutropenia (FN)	University Hospital Basel Switzerland	December 21 2022	--
NCT05593601	Recruiting	Colonization Asymptomatic	Mahidol University	November 24 2022	Phase 4
NCT05511129	Active not recruiting	COVID-19\|Nosocomial Infection	Fondation Hôpital Saint-Joseph	May 12 2022	--
NCT04239326	Completed	Tuberculosis Multidrug-Resistant	Foundation for Innovative New Diagnostics Switzerland	April 16 2021	--

References

Chemical Information & Solubility

Molecular Weight	585.6+x18	Formula	C₂₂H₄₃N₅O₁₃.xH₂O
CAS No.	1257517-67-1	SDF	Download Amikacin hydrate SDF
Smiles	C1C(C(C(C(C1NC(=O)C(CCN)O)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(C(C(C(O3)CN)O)O)O)N.O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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