Home MAPK p38 MAPK inhibitor Adezmapimod hydrochloride For research use only.

Adezmapimod hydrochloride

Synonyms: RWJ 64809 hydrochloride, SB 203580 hydrochloride

Adezmapimod hydrochloride (RWJ 64809 hydrochloride, SB 203580 hydrochloride) is an inhibitor of the MAPK family member termed as stress-activated protein kinase 2a(SAPK2a; also known as p38). It exhibits IC50 of SAPK2a/p38 and SAPK2b/p38β2 with IC50 values of 50 nM and 500 nM respectively and can be used in research of chronic inflammatory diseases, such as rheumatoid arthritis.

Adezmapimod hydrochloride Chemical Structure

Adezmapimod hydrochloride Chemical Structure

CAS No. 869185-85-3

Purity & Quality Control

Batch: E479101 DMSO]83 mg/mL]false]Water]4 mg/mL]false]Ethanol]Insoluble]false Purity: 98.26%
98.26

Adezmapimod hydrochloride Related Products

Signaling Pathway

p38 MAPK Signaling Pathways

p38 MAPK Signaling Pathway

Biological Activity

Description Adezmapimod hydrochloride (RWJ 64809 hydrochloride, SB 203580 hydrochloride) is an inhibitor of the MAPK family member termed as stress-activated protein kinase 2a(SAPK2a; also known as p38). It exhibits IC50 of SAPK2a/p38 and SAPK2b/p38β2 with IC50 values of 50 nM and 500 nM respectively and can be used in research of chronic inflammatory diseases, such as rheumatoid arthritis.

Chemical Information & Solubility

Molecular Weight 413.90 Formula

C21H16FN3OS.ClH
CAS No. 869185-85-3 SDF Download Adezmapimod hydrochloride SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 83 mg/mL ( (200.53 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 4 mg/mL

Ethanol : Insoluble


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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