Home Metabolism Phospholipase (e.g. PLA) inhibitor AACOCF3 For research use only.

AACOCF3

Synonyms: Arachidonyl trifluoromethyl keton

AACOCF3 (Arachidonyl trifluoromethyl ketone) is an inhibitor of cytosolic phospholipase A2 (cPLA2) and calcium-independent phospholipase A2(iPLA2) with IC50 of 1.5 μM and 6.0 μM, respectively. It inhibits aortic osteoinductive signalling and vascular calcification in the cholecalciferol-overload mouse model.

AACOCF3 Chemical Structure

AACOCF3 Chemical Structure

CAS No. 149301-79-1

Purity & Quality Control

Batch: E111601 DMSO]71 mg/mL]false]Ethanol]35 mg/mL]false]Water]Insoluble]false Purity: 100.00%
100.00

AACOCF3 Related Products

Signaling Pathway

Phospholipase (e.g. PLA) Signaling Pathways

Phospholipase (e.g. PLA) Signaling Pathway

Biological Activity

Description AACOCF3 (Arachidonyl trifluoromethyl ketone) is an inhibitor of cytosolic phospholipase A2 (cPLA2) and calcium-independent phospholipase A2(iPLA2) with IC50 of 1.5 μM and 6.0 μM, respectively. It inhibits aortic osteoinductive signalling and vascular calcification in the cholecalciferol-overload mouse model.

Chemical Information & Solubility

Molecular Weight 356.47 Formula

C21H31F3O
CAS No. 149301-79-1 SDF Download AACOCF3 SDF
Storage (From the date of receipt) 2 years  -20°C  liquid

In vitro
Batch:

DMSO : 71 mg/mL ( (199.17 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 35 mg/mL

Water : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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