Home Neuronal Signaling COX inhibitor Sulindac For research use only.

Sulindac

Synonyms: MK-231

Sulindac(MK-231) is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions.

Sulindac Chemical Structure

Sulindac Chemical Structure

CAS No. 38194-50-2

Purity & Quality Control

Sulindac Related Products

Signaling Pathway

COX Signaling Pathways

COX Signaling Pathway

Biological Activity

Description Sulindac(MK-231) is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions.
Targets
COX [1]
In vitro
In vitro

Sulindac and its metabolites sulindac sulfide and sulindac sulfone can also inhibit the NF-kappaB pathway in both colon cancer and other cell lines, due to sulindac-mediated decreases in IKKbeta kinase activity. [1] Sulindac sulfide significantly reduces cell number in both preconfluent and confluent cultures of HT-29 cells with the sulfide showing approximately 4-fold greater potency. Sulindac sulfide inhibits the growth of a variety of tumor cell lines derived from other tissues, as well as normal epithelial cells and fibroblasts. [2] Sulindac sulphide abrogates beta-catenin/TCF-mediated transcription in the CRC cell lines DLD1 and SW480, and decreases the levels of nonphosphorylated beta-catenin. [3]
In Vivo
In vivo

Sulindac not only inhibits tumor formation but decreases small bowel Cox-2 and prostaglandin E(2) to baseline and restored normal levels of apoptosis in a murine modelof familial adenomatous polyposis. [4] Sulindac reduces the tumor number by 95% but does not alter the levels of PGE2 and LTB4 in intestinal tissues in Min/+爉ice. Sulindac reduces tumor number by 82%, whereas eicosanoid levels remained elevates in Min/+ mice. [5] Sulindac causes regression of 70-80% of small intestinal tumors in Min/+ mice within 4 days, but does not have the same impact on colonic lesions. [6]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01636128 Withdrawn
Focus of Study: Drug Response Biomarkers Chemoprevention Neoplasms
Cancer Prevention Pharmaceuticals Inc.|University of Arizona
 March 2014 Phase 2
NCT01843179 Withdrawn
Acute Myeloid Leukemia
Massachusetts General Hospital
 January 2014 Phase 2
NCT00392665 Terminated
Squamous Cell Carcinoma of the Head and Neck (SCCHN)
Massachusetts General Hospital|Dana-Farber Cancer Institute|Emory University|University of North Carolina Chapel Hill|Genentech Inc.|OSI Pharmaceuticals
 October 2006 Phase 2

Chemical Information & Solubility

Molecular Weight 356.41 Formula

C20H17FO3S
CAS No. 38194-50-2 SDF Download Sulindac SDF
Smiles CC1=C(C2=C(C1=CC3=CC=C(C=C3)S(=O)C)C=CC(=C2)F)CC(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 71 mg/mL ( (199.2 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 9 mg/mL

Water : Insoluble


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In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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