Home Transmembrane Transporters Potassium Channel inhibitor Quinine HCl Dihydrate For research use only.

Quinine HCl Dihydrate

Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.

Quinine HCl Dihydrate Chemical Structure

Quinine HCl Dihydrate Chemical Structure

CAS No. 6119-47-7

Purity & Quality Control

Quinine HCl Dihydrate Related Products

Signaling Pathway

Potassium Channel Signaling Pathways

Potassium Channel Signaling Pathway

Biological Activity

Description Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.
Targets
Potassium channel [1]
In vitro
In vitro Quinine blocks Cx36 and Cx50 junctional currents in a reversible and concentration-dependent manner with half maximal blocking concentrations of 32 mM and 73 mM, respectively. Quinine induces slow transitions between open and fully closed states that decreased open probability of the channel. Quinine thus offers a potentially useful method to block certain types of gap junction channels, including those between neurons that are formed by Cx36. [1] Quinine, a K+ channel blocker, prevents formation of tumor necrosis factor (TNF) as well as the subsequent hepatic DNA fragmentation and liver enzyme leakage. [2] Quinine elicits Fos-like immunoreactivity (FLI) concentrated in the medial third of the nucleus; acid elicited more broadly distributed FLI concentrated farther laterally. [3] Quinine has a relatively weak effect on doxorubicin accumulation but was able to completely restore doxorubicin sensitivity in the resistant cells. Quinine also modifies the intracellular tolerance to doxorubicin, which suggests that it is able to modify drug distribution within the cells. [4] Quinine primarily blocks the whole cell potassium currents (IK) in a voltage-dependent manner. Quinine also reduces the size of sodium currents (INa) in a use-dependent manner, while leaving calcium currents (ICa) relatively unaffected. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04873011 Unknown status
Obesity
Universitaire Ziekenhuizen KU Leuven
 October 29 2020 Phase 1
NCT02817919 Completed
Malaria
African Collaborating Centre for Pharmacovigilance|Kintampo Health Research Centre Ghana|University of Health and Allied Sciences
 May 2016 --
NCT02598713 Recruiting
Pneumonia|Aspiration
Massachusetts General Hospital
 December 2015 Phase 1

Chemical Information & Solubility

Molecular Weight 396.91 Formula

C20H24N2O2.HCl.2H2O
CAS No. 6119-47-7 SDF Download Quinine HCl Dihydrate SDF
Smiles COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.O.O.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 79 mg/mL ( (199.03 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 79 mg/mL

Water : 43 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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