Home Metabolism Peroxidases inhibitor Propylthiouracil For research use only.

Propylthiouracil

Synonyms: NSC 6498, NSC 70461

Propylthiouracil (NSC 6498, NSC 70461) is a thyroperoxidase and 5'-deiodinase inhibitor, used to treat hyperthyroidism.

Propylthiouracil Chemical Structure

Propylthiouracil Chemical Structure

CAS No. 51-52-5

Purity & Quality Control

Batch: S198801 DMSO]34 mg/mL]false]Ethanol]19 mg/mL]false]Water]Insoluble]false Purity: 99.46%
99.46

Propylthiouracil Related Products

Biological Activity

Description Propylthiouracil (NSC 6498, NSC 70461) is a thyroperoxidase and 5'-deiodinase inhibitor, used to treat hyperthyroidism.
Targets
thyroperoxidase [1] 5'-deiodinase [1]
In Vivo
In vivo Propylthiouracil-induced hypothyroidism reduces oxidative damage in the lung, hepatic, renal and ileal tissues probably due to hypometabolism in rats, which is associated with decreased production of reactive oxygen metabolites and enhancement of antioxidant mechanisms. [1] Propylthiouracil-induced congenital hypothyroidism upregulates vimentin phosphorylation and depletes antioxidant defenses in immature rat testis. [2] Propylthiouracil results in lesser concentrations of thyroxine (T4) and triiodothyronine (T3), greater concentrations of follicle stimulating hormone (FSH) and luteinizing hormone (LH) peptides, and increase in steroidogenic gene expression after 12 hours and 48 hours in zebrafish. [3]Propylthiouracil-induced hypothyroidism is associated with increased tolerance of the isolated rat heart toischaemia-reperfusion. [4] Propylthiouracil (PTU) dramatically reduces thyroid hormones on PND21 and produced deficits in body weight that persisted to adulthood in developing rats. [5] Propylthiouracil inhibits both the synthesis of thyroid hormones in the thyroid gland and the conversion of T4 to its active form, T3. Propylthiouracil treatment significantly increases circulating TSH at both P3 and P7. Propylthiouracil exposure of adult rats, at a dose inducing modest reductions in circulating T4 concentrations and no significant effect on brain BDNF, significantly alteres the thyroid hormones and hippocampal BDNF levels in the offspring at 3 and 7 d after birth. [6]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02390180 Completed
Taste Qualities|Primary Tastes
Purdue University
 October 2014 --
NCT01097915 Completed
Dysgeusia
University of Cagliari
 October 2009 --
NCT00570466 Completed
Type 2 Diabetes
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|Baylor College of Medicine
 January 2008 Not Applicable

Chemical Information & Solubility

Molecular Weight 170.23 Formula

C7H10N2OS
CAS No. 51-52-5 SDF Download Propylthiouracil SDF
Smiles CCCC1=CC(=O)NC(=S)N1
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 34 mg/mL ( (199.72 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 19 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Propylthiouracil | Propylthiouracil supplier | purchase Propylthiouracil | Propylthiouracil cost | Propylthiouracil manufacturer | order Propylthiouracil | Propylthiouracil distributor