Home Metabolism Peroxidases inhibitor Verdiperstat For research use only.

Verdiperstat

Synonyms: AZD3241, BHV-3241

Verdiperstat (AZD3241, BHV-3241) is a selective, orally active and irreversible inhibitor of myeloperoxidase (MPO) with IC50 of 630 nM. Verdiperstat (AZD3241) can be used in the research of neurodegenerative brain disorders.

Verdiperstat Chemical Structure

Verdiperstat Chemical Structure

CAS No. 890655-80-8

Purity & Quality Control

Verdiperstat Related Products

Biological Activity

Description Verdiperstat (AZD3241, BHV-3241) is a selective, orally active and irreversible inhibitor of myeloperoxidase (MPO) with IC50 of 630 nM. Verdiperstat (AZD3241) can be used in the research of neurodegenerative brain disorders.
Targets
MPO [1]
(Cell-free assay)
630 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05184569 Recruiting
Semantic Dementia
Peter Ljubenkov MD|National Institutes of Health (NIH)|Alzheimer''s Association|National Institute on Aging (NIA)|University of California San Francisco
 April 14 2022 Phase 1
NCT00914303 Completed
Healthy
AstraZeneca
 June 2009 Phase 1

Chemical Information & Solubility

Molecular Weight 253.32 Formula

C11H15N3O2S
CAS No. 890655-80-8 SDF --
Smiles CC(C)OCCN1C2=C(C(=O)NC1=S)NC=C2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 51 mg/mL ( (201.32 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 10 mg/mL

Water : Insoluble


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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