Home Neuronal Signaling 5-HT Receptor antagonist - Dopamine Receptor antagonist Olanzapine For research use only.

Olanzapine

Synonyms: LY170053,Zyprexa, Zalasta, Zolafren, Olzapin, Oferta, Zypadhera

Olanzapine (LY170053,Zyprexa, Zalasta, Zolafren, Olzapin, Oferta, Zypadhera) is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.

Olanzapine Chemical Structure

Olanzapine Chemical Structure

CAS No. 132539-06-1

Purity & Quality Control

Olanzapine Related Products

Signaling Pathway

5-HT Receptor Signaling Pathways

5-HT Receptor Signaling Pathway

Biological Activity

Description Olanzapine (LY170053,Zyprexa, Zalasta, Zolafren, Olzapin, Oferta, Zypadhera) is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.
Targets
5-HT2 [1] D2 receptor [1]
In vitro
In vitro

Olanzapine interacts with key receptors of interest in schizophrenia, having a nanomolar affinity for dopaminergic, serotonergic, alpha 1-adrenergic, and muscarinic receptors. Olanzapine has a receptor profile that is similar to that of clozapine: it is relatively nonselective at dopamine receptor subtypes and it shows selectivity for mesolimbic and mesocortical over striatal dopamine tracts (electrophysiology; Fos). [1]
In Vivo
In vivo

Olanzapine is a potent antagonist at DA receptors (DOPAC levels; pergolide-stimulated increases in plasma corticosterone) and 5-HT receptors (quipazine-stimulated increases in corticosterone), but is weaker at alpha-adrenergic and muscarinic receptors. [1] Olanzapine combined with fluoxetine produces robust, sustained increases of extracellular levels of dopamine ([DA](ex)) and norepinephrine ([NE](ex)) up to 361% and 272% of the baseline in rat prefrontal cortex, respectively, which are significantly greater than either drug alone. [2] Olanzapine at 0.5 mg/kg, 3 mg/kg and 10 mg/kg (s.c.) dose-dependently increases the extracellular dopamine (DA) and norepinephrine (NE) levels in rat prefrontal cortex, nucleus accumbens and striatum. Olanzapine also increases extracellular levels of a DA metabolite, DOPAC, and tissue concentrations of a released DA metabolite, 3-methoxytyramine. [3] Olanzapine results in an 8-11% reduction in mean fresh brain weights as well as left cerebrum fresh weights and volumes in macaque monkeys. [4] Olanzapine results in substantial increases in adiposity: increased total body fat reflecting marked increases in subcutaneous and visceral adipose stores. Olanzapine results in marked hepatic insulin resistance. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06288854 Not yet recruiting
Weight Gain
Rajavithi Hospital
 April 3 2024 Not Applicable
NCT06319170 Recruiting
Schizophrenia Schizoaffective Disorder
Teva Branded Pharmaceutical Products R&D Inc.
 March 28 2024 Phase 1
NCT06315283 Recruiting
Schizophrenia
Teva Branded Pharmaceutical Products R&D Inc.
 March 20 2024 Phase 1
NCT06253546 Recruiting
Schizophrenia
Teva Branded Pharmaceutical Products R&D Inc.
 March 28 2024 Phase 1

Chemical Information & Solubility

Molecular Weight 312.43975 Formula

C17H20N4S
CAS No. 132539-06-1 SDF Download Olanzapine SDF
Smiles CC1=CC2=C(S1)NC3=CC=CC=C3N=C2N4CCN(CC4)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 62 mg/mL ( (198.43 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 15 mg/mL

Water : Insoluble


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In vivo
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