Home Neuronal Signaling COX inhibitor Meloxicam For research use only.

Meloxicam

Meloxicam is a selective COX inhibitor, used to relieve pain and fever effects.

Meloxicam Chemical Structure

Meloxicam Chemical Structure

CAS No. 71125-38-7

Purity & Quality Control

Batch: S173401 DMSO]30 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.91%
99.91

Meloxicam Related Products

Signaling Pathway

COX Signaling Pathways

COX Signaling Pathway

Biological Activity

Description Meloxicam is a selective COX inhibitor, used to relieve pain and fever effects.
Targets
COX [1]
In vitro
In vitro Meloxicam significantly reduces HCA-7 and Moser-S colony size. Meloxicam significantly inhibits HCA-7 colony and tumor growth but has no effect on the growth of the COX-2 negative HCT-116 cells. [1] Meloxicam inhibits PGE(2) production, proliferation and invasiveness especially in MG-63 cells, which express relatively high levels of COX-2. Meloxicam causes apoptosis and upregulates Bax mRNA and protein in MG-63 cell culture. [2]
In Vivo
In vivo Meloxicam suppresses LM-8 tumor growth and lung metastasis in vivo mouse model. [2] Meloxicam causes a significant reduction in lameness at post injection hour (PIH) 8 and 24 and tends to reduce effusion in horse. Meloxicam significantly suppresses synovial fluid (SF) prostaglandin E2 and substance P release at PIH 8 and bradykinin at PIH 24 compared to placebo treatment in horse. Meloxicam reduces general MMP activity at PIH 8 and 24 in horse. [3] Meloxicam- or flunixin-treated horses has improved postoperative pain scores and clinical variables, compared with SS-treated horses. Meloxicam results in high numbers of neutrophils in ischemia-injured tissue of horse. [4] Meloxicam administration significantly suppresses PGE2 concentrations in blood and synovial fluid at days 7 and 21, but has no effect on concentrations of TXB2 in blood or PGE2 in gastric mucosa in dogs. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05702827 Recruiting
Stress Urinary Incontinence|Surgical Incision|Pain Vulva
TriHealth Inc.
 January 23 2023 Phase 3

Chemical Information & Solubility

Molecular Weight 351.4 Formula

C14H13N3O4S2
CAS No. 71125-38-7 SDF Download Meloxicam SDF
Smiles CC1=CN=C(S1)NC(=O)C2=C(C3=CC=CC=C3S(=O)(=O)N2C)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 30 mg/mL ( (85.37 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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