Home Neuronal Signaling COX inhibitor Ketoprofen For research use only.

Ketoprofen

Synonyms: RP-19583

Ketoprofen (RP-19583) is a dual COX1/2 inhibitor, used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains.

Ketoprofen Chemical Structure

Ketoprofen Chemical Structure

CAS No. 22071-15-4

Purity & Quality Control

Ketoprofen Related Products

Signaling Pathway

COX Signaling Pathways

COX Signaling Pathway

Biological Activity

Description Ketoprofen (RP-19583) is a dual COX1/2 inhibitor, used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains.
Targets
COX-1 [1] COX-2 [1]
In vitro
In vitro Ketoprofen combined with UVB irradiation induces the cytotoxicity and suppresses DNA synthesis in HaCaT cells in a concentration-dependent manner. Ketoprofen combined with UVB irradiation inhibits the cell growth and induces G2/M cell cycle arrest by modulating the levels of cdc2, cyclin B1, Chk1, Tyr15-phosphorylated cdc2 and p21. Ketoprofen combined with UVB irradiation also provokes a striking accumulation of cyclin B1-cdc2-p21 complexes, concomitantly with an increase in the levels of Tyr15-phosphorylated cdc2 and p21 protein. Ketoprofen combined with UVB irradiation accentuates the apoptotic response to UVB radiation in HaCaT cells as evidenced by DAPI staining. [1]
In Vivo
In vivo Ketoprofen at 1% level in suitable topical vehicles can effectively inhibit GCF-LTB4 and GCF-PGE2 and positively alter alveolar bone activity in the ligature-induced model of periodontitis in the monkey. [2] Ketoprofen (3.63 mg/kg bwt) reduces hoof pain andlameness to a greater extent than the 2.2 mg/kg dose and phenylbutazone. [3] Ketoprofen is more effective than local anesthesia (LA), or caudal epidural anesthesia (EPI) in decreasing cortisol and partially reverses the reduction in average daily gain (ADG) following castration. [4] Ketoprofen (40 and 80 mg/kg diet) reduces the incidence of transitional cell carcinoma of the urinary bladder by >70% from that seen in dietary mice. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04678076 Completed
Healthy
Aziende Chimiche Riunite Angelini Francesco S.p.A|Cross Research S.A.
 July 23 2018 Phase 1
NCT02796547 Withdrawn
Episiotomy
Brugmann University Hospital
 July 14 2016 Phase 2
NCT02350296 Completed
Pain Disorders
Dompé Farmaceutici S.p.A|Cross Research S.A.
 November 26 2014 Phase 1
NCT01541059 Completed
Third Molar Extraction
Centre Hospitalier Universitaire de Nīmes
 June 2012 Phase 4

Chemical Information & Solubility

Molecular Weight 254.28 Formula

C16H14O3
CAS No. 22071-15-4 SDF Download Ketoprofen SDF
Smiles CC(C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 51 mg/mL ( (200.56 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 51 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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