Home Metabolism Retinoid Receptor agonist Acitretin For research use only.

Acitretin

Synonyms: Etretin, RO 10-1670

Acitretin (Etretin, RO 10-1670) is a second generation retinoid used for psoriasis.

Acitretin Chemical Structure

Acitretin Chemical Structure

CAS No. 55079-83-9

Purity & Quality Control

Acitretin Related Products

Biological Activity

Description Acitretin (Etretin, RO 10-1670) is a second generation retinoid used for psoriasis.
In vitro
In vitro Acitretin stimulates ADAM10 promoter activity with an EC(50) of 1.5 mM and leads to an increase of mature ADAM10 protein that results in a two- to three-fold increase of the ratio between alpha- and beta-secretase activity in neuroblastoma cells. [1] Acitretin (5-20 μM) impairs mitochondrial phosphorylation efficiency as demonstrated by the decrease in the state 3 respiration and ATP levels, and by the increase in the lag phase of ADP phosphorylation cycle, without affecting the membrane potential. Acitretin induces Ca(2+)-mediated mitochondrial permeability transition (MPT) and decreased the adenine nucleotide translocase (ANT) content. [2] Acitretin preferentially inhibits the growth of SCL-1 cells in a dose- and time-dependent manner, but not of non-malignant keratinocyte HaCaT cells. Acitretin increases the levels of CD95 (Fas), CD95-ligand and Fas-associated death domain. Acitretin is able to induce apoptosis in skin cancer cells possibly via death receptor CD95 apoptosis pathway without affecting the viability of normal keratinocyte. [3]
In Vivo
In vivo Acitretin undergoes alpha-oxidation, chain shortening O-demethylation, and glucuronidation in the perfused rat liver. [4] Acitretin rapidly appears in liver and muscle of rats, where it undergoes redistribution into skin and adipose tissue. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04841187 Completed
Psoriasis
Assistance Publique - Hôpitaux de Paris|Société de Dermatologie Française
 September 6 2021 --
NCT04245319 Unknown status
Hyperlipidemias|Xerosis|Depression|Liver Diseases
Cairo University
 January 1 2020 Not Applicable
NCT05203354 Completed
Psoriasis
Mahmoud Ahmed Ali Ahmed|Aswan University Hospital
 September 1 2018 Phase 4
NCT01039142 Completed
Psoriasis
Post Graduate Institute of Medical Education and Research Chandigarh|PIMERIndia
 March 2008 Phase 4
NCT00488384 Withdrawn
Carcinoma Squamous Cell
Günther Hofbauer|University of Zurich
 June 2007 Phase 4
NCT00156247 Completed
Psoriasis
University of Medicine and Dentistry of New Jersey|Connetics Corp.|Rutgers The State University of New Jersey
 September 2005 Phase 2

Chemical Information & Solubility

Molecular Weight 326.43 Formula

C21H26O3
CAS No. 55079-83-9 SDF Download Acitretin SDF
Smiles CC1=CC(=C(C(=C1C=CC(=CC=CC(=CC(=O)O)C)C)C)C)OC
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 65 mg/mL ( (199.12 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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