Home Metabolism Hydroxylase inhibitor 4-Chloro-DL-phenylalanine For research use only.

4-Chloro-DL-phenylalanine

Synonyms: Fenclonine, PCPA, CP-10188

4-Chloro-DL-phenylalanine (Fenclonine, PCPA, CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). 4-Chloro-DL-phenylalanine acts pharmacologically to deplete endogenous levels of serotonin.

4-Chloro-DL-phenylalanine Chemical Structure

4-Chloro-DL-phenylalanine Chemical Structure

CAS No. 7424-00-2

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4-Chloro-DL-phenylalanine Related Products

Signaling Pathway

Hydroxylase Signaling Pathways

Hydroxylase Signaling Pathway

Biological Activity

Description 4-Chloro-DL-phenylalanine (Fenclonine, PCPA, CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). 4-Chloro-DL-phenylalanine acts pharmacologically to deplete endogenous levels of serotonin.
Targets
tryptophan hydroxylase [1]
In Vivo
In vivo 4-Chloro-DL-phenylalanine(PCPA) markedly attenuates MCT(monocrotaline)-induced pulmonary vascular remodeling and lung inflammation, inhibits the expression of Tph-1 and SERT and suppresses the expression of MMP-2/-9, TIMP-1/-2, interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and intercellular adhesion molecule-1 (ICAM-1). PCPA inhibits 5-HT by suppressing Tph-1, regulating SERT and the serotonin downstream signaling pathway[1].
Animal Research Animal Models Sprague-Dawley (SD) rats 
Dosages 50 or 100 mg/kg/day
Administration i.p.

Chemical Information & Solubility

Molecular Weight 199.63 Formula

C9H10ClNO2
CAS No. 7424-00-2 SDF Download 4-Chloro-DL-phenylalanine SDF
Smiles C1=CC(=CC=C1CC(C(=O)O)N)Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 3.75 mg/mL

DMSO : 2 mg/mL ( (10.01 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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