Home Metabolism Hydroxylase inhibitor Ro 61-8048 For research use only.

Ro 61-8048

Ro 61-8048 is a high-affinity kynurenine 3-hydroxylase (KMO) inhibitor with IC50 and Ki of 37 nM and 4.8 nM, respectively.

Ro 61-8048 Chemical Structure

Ro 61-8048 Chemical Structure

CAS No. 199666-03-0

Purity & Quality Control

Ro 61-8048 Related Products

Signaling Pathway

Hydroxylase Signaling Pathways

Hydroxylase Signaling Pathway

Biological Activity

Description Ro 61-8048 is a high-affinity kynurenine 3-hydroxylase (KMO) inhibitor with IC50 and Ki of 37 nM and 4.8 nM, respectively.
Targets
KMO [1]
(Cell-free assay)		 KMO [1]
(Cell-free assay)
4.8 nM(Ki) 37 nM
In Vivo
In vivo In gerbils and rats, Ro 61-8048 (30 mg/kg, p.o.) causes kynurenine 3-hydroxylase inhibition. [1] In models of focal or global brain ischemia, Ro 61-8048 (40 mg/kg, p.o.) reduce ischemic brain damage. [2] In a hamster model of paroxysmal dyskinesia, Ro 61-8048 (150 mg/kg i.p.) significantly reduces the severity of dystonia without leading to marked central side effects. [3] addition, prenatal inhibition of the kynurenine pathway by Ro 61-8048 leads to structural changes in the hippocampus of adult rat offspring. [4]
Animal Research Animal Models Male albino rats and female gerbils
Dosages 30 μmol/kg
Administration p.o.

Chemical Information & Solubility

Molecular Weight 421.45 Formula

C17H15N3O6S2
CAS No. 199666-03-0 SDF Download Ro 61-8048 SDF
Smiles COC1=C(C=C(C=C1)S(=O)(=O)NC2=NC(=CS2)C3=CC(=CC=C3)[N+](=O)[O-])OC
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 84 mg/mL ( (199.31 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Ro 61-8048|Ro 61-8048 ic50|Ro 61-8048 price|Ro 61-8048 cost|Ro 61-8048 solubility dmso|Ro 61-8048 purchase|Ro 61-8048 manufacturer|Ro 61-8048 research buy|Ro 61-8048 order|Ro 61-8048 mouse|Ro 61-8048 chemical structure|Ro 61-8048 mw|Ro 61-8048 molecular weight|Ro 61-8048 datasheet|Ro 61-8048 supplier|Ro 61-8048 in vitro|Ro 61-8048 cell line|Ro 61-8048 concentration|Ro 61-8048 nmr|Ro 61-8048 in vivo|Ro 61-8048 clinical trial|Ro 61-8048 inhibitor|Ro 61-8048 Metabolism inhibitor