Home Immunology & Inflammation STING activator - IFN activator 3',3'-cGAMP For research use only.

3',3'-cGAMP

Synonyms: 3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP

3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING), thereby inducing an antiviral state and the secretion of type I IFNs.

3',3'-cGAMP Chemical Structure

3',3'-cGAMP Chemical Structure

CAS No. 849214-04-6(freeacid)

Purity & Quality Control

Batch: S790501 Water]100 mg/mL]false]DMSO]20 mg/mL]false]Ethanol]Insoluble]false Purity: 99.84%
99.84

3',3'-cGAMP Related Products

Biological Activity

Description 3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING), thereby inducing an antiviral state and the secretion of type I IFNs.
Targets
STING [1]
In Vivo
In vivo

Sublingual immunization of mice with Bacillus anthracis protective antigen (PA) and the STING ligand 3′3′-cGAMP promotes PA-specific serum IgG Ab responses of the same magnitude as those induced after immunization with PA and the experimental adjuvants cholera toxin (CT). 3′3′-cGAMP also promotes serum anti-PA IgA and IgA-producing cells in the bone marrow. Furthermore, the saliva of mice immunized with 3′3′-cGAMP exhibits similar levels of PA-specific IgA Abs as groups immunized with CT as adjuvant. The adjuvant activity of 3′3′-cGAMP is associated with mixed Th1, Th2, and Th17 responses. 3′3′-cGAMP also induces rapid IFN-β and IL-10 responses in sublingual tissues and cervical lymph nodes, and TGF-β responses in the cervical lymph nodes, which can contribute to promoting IgA responses after sublingual immunization.[1]
Animal Research Animal Models 9–12 week old female C57BL/6J mice
Dosages 10 μg
Administration Oral gavage
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05705986 Recruiting
Relapse Remitting Multiple Sclerosis
Thomas Jefferson University
 February 26 2021 --
NCT02986867 Completed
Urothelial Carcinoma|Melanoma|Cervical Carcinoma in Situ
University of Texas Southwestern Medical Center
 June 13 2017 Not Applicable

Chemical Information & Solubility

Molecular Weight 672.4 Formula

C20H24N10O13 P2·xNa+
CAS No. 849214-04-6(freeacid) SDF --
Smiles C1C2C(C(C(O2)N3C=NC4=C3N=C(NC4=O)N)O)OP(=O)(OCC5C(C(C(O5)N6C=NC7=C(N=CN=C76)N)O)OP(=O)(O1)O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 100 mg/mL

DMSO : 20 mg/mL ( (29.74 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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