Home Neuronal Signaling 5-HT Receptor agonist 1-Phenylbiguanide For research use only.

1-Phenylbiguanide

Synonyms: Phenylbiguanide, PBG, N-Phenylbiguanide

1-Phenylbiguanide (Phenylbiguanide, PBG, N-Phenylbiguanide) is a 5-hydroxytryptamine3 (5-HT3) receptor agonist with EC50 of 3.0 μM.

1-Phenylbiguanide Chemical Structure

1-Phenylbiguanide Chemical Structure

CAS No. 102-02-3

Purity & Quality Control

Batch: S257801 DMSO]35 mg/mL]false]Water]35 mg/mL]false]Ethanol]17 mg/mL]false Purity: 99.50%
99.50

1-Phenylbiguanide Related Products

Signaling Pathway

5-HT Receptor Signaling Pathways

5-HT Receptor Signaling Pathway

Biological Activity

Description 1-Phenylbiguanide (Phenylbiguanide, PBG, N-Phenylbiguanide) is a 5-hydroxytryptamine3 (5-HT3) receptor agonist with EC50 of 3.0 μM.
Targets
5-HT3 receptor [1]
(Cell-free assay)
3.0 μM(EC50)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06047574 Recruiting
Polycystic Ovary Syndrome
Shanghai 10th People''s Hospital
 September 18 2023 --
NCT05856578 Active not recruiting
Type 2 Diabetes Mellitus
Nanjing First Hospital Nanjing Medical University
 March 15 2022 Phase 4
NCT05892224 Recruiting
Obesity|Functional Neuroimaging
Shanghai 10th People''s Hospital
 January 1 2022 --
NCT04690634 Completed
Polycystic Ovary Syndrome
Shanghai 10th People''s Hospital
 May 1 2020 Not Applicable
NCT04700839 Completed
Polycystic Ovary Syndrome
Shanghai 10th People''s Hospital
 May 1 2020 Phase 4
NCT04373967 Unknown status
Type 2 Diabetes
Chia Tai Tianqing Pharmaceutical Group Co. Ltd.
 April 29 2020 Phase 3

Chemical Information & Solubility

Molecular Weight 177.21 Formula

C8H11N5
CAS No. 102-02-3 SDF --
Smiles C1=CC=C(C=C1)N=C(N)N=C(N)N
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 35 mg/mL ( (197.5 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 35 mg/mL

Ethanol : 17 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy 1-Phenylbiguanide | 1-Phenylbiguanide supplier | purchase 1-Phenylbiguanide | 1-Phenylbiguanide cost | 1-Phenylbiguanide manufacturer | order 1-Phenylbiguanide | 1-Phenylbiguanide distributor