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Carbonic Anhydrase

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Carbonic Anhydrase Products

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Catalog No. Product Name Information Product Use Citations Product Validations
S2866 U-104 U-104 (MST-104, NSC 213841, SLC-0111, WBI-5111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki of 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II.
Nat Immunol, 2023, 24(11):1867-1878
Front Oncol, 2023, 13:1118268
J Pharmacol Sci, 2023, 10.1016/j.jphs.2023.10.003
S1438 Topiramate Topiramate (MCN 4853, RWJ 17021) is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.
Cell Rep, 2022, 40(5):111153
Anticancer Res, 2021, 41(2):687-697
Neuropharmacology, 2020, 182:108371
S4506 Acetazolamide Acetazolamide (Diamox), a potent carbonic anhydrase (CA) inhibitor, is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure(IOP).
Cell Commun Signal, 2024, 22(1):383
Biomed Pharmacother, 2022, 156:113982
Cancer Sci, 2022, 113(8):2642-2653
S1375 Dorzolamide HCl Dorzolamide (MK-507, L-671152) HCl is a water-soluble, potent inhibitor of human carbonic anhydrase II and IV with Ki of 1.9 nM and 31 nM, respectively, used as anti-glaucoma agent.
Neuro Oncol, 2021, noab156
ETD, 2020, N/A
S3178 Brinzolamide Brinzolamide (AL-4862) is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.
bioRxiv, 2024, 2024.03.13.584872
Chinese Journal of Tissue Engineering Research, 2024, (28): 4461-4468.
ETD, 2020, N/A
S3697 Mafenide hydrochloride Mafenide is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
ETD, 2020, N/A
S9742 Indisulam Indisulam (E7070), a sulfonamide anticancer agent, is a potent carbonic anhydrase (CA) inhibitor that inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Indisulam suppresses the expression of cyclin E and phosphorylation of CDK2, both of which are essential for the G1 to S transition.
Cancer Cell, 2022, S1535-6108(22)00312-9
S4725 Benzenesulfonamide Benzenesulfonamide (Benzenesulphonamide, Benzosulfonamide, Phenyl sulfonamide, Benzene sulfonamide) is an inhibitor of carbonic anhydrases.
Br J Pharmacol, 2016, 173(6):1018-32
S2603 Tioxolone Tioxolone(Thioxolone) is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM.
S1736 Methocarbamol Methocarbamol (AHR 85) is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.
S2177 Dichlorphenamide Dichlorphenamide (Diclofenamide) is a sulfonamide and a carbonic anhydrase inhibitor of the meta-Disulfamoylbenzene class.
S4039 Methazolamide Methazolamide (CL 8490) is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.
S3647 Mafenide Acetate Mafenide Acetate is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
A2578 Girentuximab (Anti-CA9 / Carbonic anhydrase 9) Girentuximab (Anti-CA9 / Carbonic anhydrase 9) is a chimeric monoclonal antibody that targets and binds to carbonic anhydrase IX (CAIX), a cell surface glycoprotein ubiquitously expressed in clear cell renal cell carcinoma (ccRCC). MW:145.5 KD.
S4998 2-Aminobenzenesulfonamide 2-Aminobenzenesulfonamide (Orthanilamide, O-Aminobenzenesulfonamide, O-Sulfanilamide, Benzenesulfonamide) is an inhibitor of carbonic anhydrase IX.
S2866 U-104 U-104 (MST-104, NSC 213841, SLC-0111, WBI-5111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki of 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II.
Nat Immunol, 2023, 24(11):1867-1878
Front Oncol, 2023, 13:1118268
J Pharmacol Sci, 2023, 10.1016/j.jphs.2023.10.003
S1438 Topiramate Topiramate (MCN 4853, RWJ 17021) is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.
Cell Rep, 2022, 40(5):111153
Anticancer Res, 2021, 41(2):687-697
Neuropharmacology, 2020, 182:108371
S4506 Acetazolamide Acetazolamide (Diamox), a potent carbonic anhydrase (CA) inhibitor, is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure(IOP).
Cell Commun Signal, 2024, 22(1):383
Biomed Pharmacother, 2022, 156:113982
Cancer Sci, 2022, 113(8):2642-2653
S1375 Dorzolamide HCl Dorzolamide (MK-507, L-671152) HCl is a water-soluble, potent inhibitor of human carbonic anhydrase II and IV with Ki of 1.9 nM and 31 nM, respectively, used as anti-glaucoma agent.
Neuro Oncol, 2021, noab156
ETD, 2020, N/A
S3178 Brinzolamide Brinzolamide (AL-4862) is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.
bioRxiv, 2024, 2024.03.13.584872
Chinese Journal of Tissue Engineering Research, 2024, (28): 4461-4468.
ETD, 2020, N/A
S3697 Mafenide hydrochloride Mafenide is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
ETD, 2020, N/A
S9742 Indisulam Indisulam (E7070), a sulfonamide anticancer agent, is a potent carbonic anhydrase (CA) inhibitor that inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Indisulam suppresses the expression of cyclin E and phosphorylation of CDK2, both of which are essential for the G1 to S transition.
Cancer Cell, 2022, S1535-6108(22)00312-9
S4725 Benzenesulfonamide Benzenesulfonamide (Benzenesulphonamide, Benzosulfonamide, Phenyl sulfonamide, Benzene sulfonamide) is an inhibitor of carbonic anhydrases.
Br J Pharmacol, 2016, 173(6):1018-32
S2603 Tioxolone Tioxolone(Thioxolone) is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM.
S1736 Methocarbamol Methocarbamol (AHR 85) is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.
S2177 Dichlorphenamide Dichlorphenamide (Diclofenamide) is a sulfonamide and a carbonic anhydrase inhibitor of the meta-Disulfamoylbenzene class.
S4039 Methazolamide Methazolamide (CL 8490) is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.
S3647 Mafenide Acetate Mafenide Acetate is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
S4998 2-Aminobenzenesulfonamide 2-Aminobenzenesulfonamide (Orthanilamide, O-Aminobenzenesulfonamide, O-Sulfanilamide, Benzenesulfonamide) is an inhibitor of carbonic anhydrase IX.
A2578 Girentuximab (Anti-CA9 / Carbonic anhydrase 9) Girentuximab (Anti-CA9 / Carbonic anhydrase 9) is a chimeric monoclonal antibody that targets and binds to carbonic anhydrase IX (CAIX), a cell surface glycoprotein ubiquitously expressed in clear cell renal cell carcinoma (ccRCC). MW:145.5 KD.

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