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Carbonic Anhydrase

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Carbonic Anhydrase Products

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Catalog No. Product Name Information Product Use Citations Product Validations
S2866 U-104 U-104 (MST-104, NSC 213841, SLC-0111, WBI-5111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki of 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II.
Nat Immunol, 2023, 24(11):1867-1878
Front Oncol, 2023, 13:1118268
J Pharmacol Sci, 2023, 10.1016/j.jphs.2023.10.003
S1438 Topiramate Topiramate (MCN 4853, RWJ 17021) is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.
Commun Biol, 2025, 8(1):28
Cell Rep, 2022, 40(5):111153
Anticancer Res, 2021, 41(2):687-697
S4506 Acetazolamide Acetazolamide (Diamox), a potent carbonic anhydrase (CA) inhibitor, is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure(IOP).
Commun Biol, 2025, 8(1):28
Cell Commun Signal, 2024, 22(1):383
Int Ophthalmol, 2024, 44(1):437
S1375 Dorzolamide HCl Dorzolamide (MK-507, L-671152) HCl is a water-soluble, potent inhibitor of human carbonic anhydrase II and IV with Ki of 1.9 nM and 31 nM, respectively, used as anti-glaucoma agent.
Neuro Oncol, 2021, noab156
ETD, 2020, N/A
S3178 Brinzolamide Brinzolamide (AL-4862) is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.
Commun Biol, 2025, 8(1):28
bioRxiv, 2024, 2024.03.13.584872
Chinese Journal of Tissue Engineering Research, 2024, (28): 4461-4468.
S3697 Mafenide hydrochloride Mafenide is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
ETD, 2020, N/A
S9742 Indisulam Indisulam (E7070), a sulfonamide anticancer agent, is a potent carbonic anhydrase (CA) inhibitor that inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Indisulam suppresses the expression of cyclin E and phosphorylation of CDK2, both of which are essential for the G1 to S transition.
Oncogenesis, 2024, 13(1):25
Cancer Cell, 2022, S1535-6108(22)00312-9
S4725 Benzenesulfonamide Benzenesulfonamide (Benzenesulphonamide, Benzosulfonamide, Phenyl sulfonamide, Benzene sulfonamide) is an inhibitor of carbonic anhydrases.
Br J Pharmacol, 2016, 173(6):1018-32
S2603 Tioxolone Tioxolone(Thioxolone) is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM.
S1736 Methocarbamol Methocarbamol (AHR 85) is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.
S2177 Dichlorphenamide Dichlorphenamide (Diclofenamide) is a sulfonamide and a carbonic anhydrase inhibitor of the meta-Disulfamoylbenzene class.
S4039 Methazolamide Methazolamide (CL 8490) is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.
S3647 Mafenide Acetate Mafenide Acetate is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
E6058New Acetazolamide sodium Acetazolamide sodium is an inhibitor of carbonic anhydrase (CA) IX with an IC50 of 30 nM for hCA IX and also inhibits hCA II with an IC50 of 13 nM. It possesses diuretic, antihypertensive, and anti-gonococcal properties.
A2578 Girentuximab (Anti-CA9 / Carbonic anhydrase 9) Girentuximab (Anti-CA9 / Carbonic anhydrase 9) is a chimeric monoclonal antibody that targets and binds to Carbonic Anhydrase IX (CAIX) / Carbonic Anhydrase 9 (CA9), a cell surface glycoprotein ubiquitously expressed in clear cell renal cell carcinoma (ccRCC). MW:145.5 KD.
S4998 2-Aminobenzenesulfonamide 2-Aminobenzenesulfonamide (Orthanilamide, O-Aminobenzenesulfonamide, O-Sulfanilamide, Benzenesulfonamide) is an inhibitor of Carbonic Anhydrase IX (CAIX) / Carbonic Anhydrase 9 (CA9).
S2866 U-104 U-104 (MST-104, NSC 213841, SLC-0111, WBI-5111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki of 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II.
Nat Immunol, 2023, 24(11):1867-1878
Front Oncol, 2023, 13:1118268
J Pharmacol Sci, 2023, 10.1016/j.jphs.2023.10.003
S1438 Topiramate Topiramate (MCN 4853, RWJ 17021) is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.
Commun Biol, 2025, 8(1):28
Cell Rep, 2022, 40(5):111153
Anticancer Res, 2021, 41(2):687-697
S4506 Acetazolamide Acetazolamide (Diamox), a potent carbonic anhydrase (CA) inhibitor, is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure(IOP).
Commun Biol, 2025, 8(1):28
Cell Commun Signal, 2024, 22(1):383
Int Ophthalmol, 2024, 44(1):437
S1375 Dorzolamide HCl Dorzolamide (MK-507, L-671152) HCl is a water-soluble, potent inhibitor of human carbonic anhydrase II and IV with Ki of 1.9 nM and 31 nM, respectively, used as anti-glaucoma agent.
Neuro Oncol, 2021, noab156
ETD, 2020, N/A
S3178 Brinzolamide Brinzolamide (AL-4862) is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.
Commun Biol, 2025, 8(1):28
bioRxiv, 2024, 2024.03.13.584872
Chinese Journal of Tissue Engineering Research, 2024, (28): 4461-4468.
S3697 Mafenide hydrochloride Mafenide is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
ETD, 2020, N/A
S9742 Indisulam Indisulam (E7070), a sulfonamide anticancer agent, is a potent carbonic anhydrase (CA) inhibitor that inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Indisulam suppresses the expression of cyclin E and phosphorylation of CDK2, both of which are essential for the G1 to S transition.
Oncogenesis, 2024, 13(1):25
Cancer Cell, 2022, S1535-6108(22)00312-9
S4725 Benzenesulfonamide Benzenesulfonamide (Benzenesulphonamide, Benzosulfonamide, Phenyl sulfonamide, Benzene sulfonamide) is an inhibitor of carbonic anhydrases.
Br J Pharmacol, 2016, 173(6):1018-32
S2603 Tioxolone Tioxolone(Thioxolone) is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM.
S1736 Methocarbamol Methocarbamol (AHR 85) is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.
S2177 Dichlorphenamide Dichlorphenamide (Diclofenamide) is a sulfonamide and a carbonic anhydrase inhibitor of the meta-Disulfamoylbenzene class.
S4039 Methazolamide Methazolamide (CL 8490) is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.
S3647 Mafenide Acetate Mafenide Acetate is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
E6058New Acetazolamide sodium Acetazolamide sodium is an inhibitor of carbonic anhydrase (CA) IX with an IC50 of 30 nM for hCA IX and also inhibits hCA II with an IC50 of 13 nM. It possesses diuretic, antihypertensive, and anti-gonococcal properties.
S4998 2-Aminobenzenesulfonamide 2-Aminobenzenesulfonamide (Orthanilamide, O-Aminobenzenesulfonamide, O-Sulfanilamide, Benzenesulfonamide) is an inhibitor of Carbonic Anhydrase IX (CAIX) / Carbonic Anhydrase 9 (CA9).
A2578 Girentuximab (Anti-CA9 / Carbonic anhydrase 9) Girentuximab (Anti-CA9 / Carbonic anhydrase 9) is a chimeric monoclonal antibody that targets and binds to Carbonic Anhydrase IX (CAIX) / Carbonic Anhydrase 9 (CA9), a cell surface glycoprotein ubiquitously expressed in clear cell renal cell carcinoma (ccRCC). MW:145.5 KD.
E6058New Acetazolamide sodium Acetazolamide sodium is an inhibitor of carbonic anhydrase (CA) IX with an IC50 of 30 nM for hCA IX and also inhibits hCA II with an IC50 of 13 nM. It possesses diuretic, antihypertensive, and anti-gonococcal properties.

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