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Sigma Receptor

Isoform-selective Products

sigma-2 receptor

Sigma Receptor Products

All (12)
Sigma Receptor Activator (1)
Sigma Receptor Antagonists (4)
Sigma Receptor Agonists (6)
New Sigma Receptor Products

Catalog No.	Product Name	Information	Product Use Citations
S0106	BD-1047 dihydrobromide	BD-1047 dihydrobromide (HBr) is a selective functional antagonist of sigma-1 (σ1) receptor, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia.	Brain Res, 2024, 1838:149011 Authorea Preprints, 2023, Neuropharmacology, 2021, 196:108360
S6981	Glycerol phenylbutyrate	Glycerol phenylbutyrate (GT4P, HPN-100M, Ravicti) is a nitrogen-binding agent and acts as a sigma-2 (σ2) receptor ligand with a pKi of 8.02. Glycerol phenylbutyrate is a prodrug in which phenylbutyrate (PBA) is released from the glycerol backbone by lipases in the gastrointestinal tract.
E7418^New	Noscapine	Noscapine ((S,R)-Noscapine) is an alkaloid derived from the opium poppy (Papaver somniferum) and is a centrally acting antitussive opiate derivative. It is a non-competitive antagonist of the bradykinin B2 receptor. It also exhibits neuroprotection by activating sigma-1 opioid receptors, which help suppress intracellular NO levels and calcium, thereby providing protection against ischemic injury.
S0295	Anavex 2-73 HCl	Anavex 2-73 (Blarcamesine, AVex-73, AE-37), an aminotetrahydrofuran derivative, is a mixed muscarinic and sigma-1/σ₁ Receptor agonist with IC50 of 0.86 μM.
S0869	Carbetapentane	Carbetapentane (Pentoxyverine, CB) is an antitussive anticonvulsant nonselective sigma-1 (σ1) agonist.
S6561	4-IBP	4-IBP is a selective σ1 receptor agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM).
E0388	WQ 1	WQ 1 is a high affinity and selective σ1 receptor antagonist with pKi values of 10.85, 6.53 and 5.80 at σ1, σ2 receptors and dopamine transporter (DAT), displaying σ1/σ2 selectivity ratio of 20893.
S2917	Cutamesine Dihydrochloride	Cutamesine dihydrochloride (SA4503 dihydrochloride,AGY94806 dihydrochloride) is a potent Sigma-1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes.
S0191	BD1063 2HCL	BD1063 2HCL (BD1063 dihydrochloride) is a potent and selective sigma-1 receptor (σ1R) antagonist with Ki of 4.43 nM.
S6950	PRE-084 hydrochloride	PRE-084 hydrochloride (HCl) is a potent, selective sigma-1 receptor (σ1, S1R) agonist with IC50 of 44 nM in the sigma receptor assay.	Free Radic Biol Med, 2025, 226:96-108
S6754	S1RA	S1RA (E-52862) is a selective sigma-1 receptor (σ1R) antagonist with a reported binding affinity of Ki = 17.0 ± 7.0 nM for human σ1 receptor , selective over the sigma-2 receptor and against a panel of other 170 receptors, enzymes, transporters and ion channels.	Int Immunopharmacol, 2024, 128:111524
S6756	Siramesine HCl	Siramesine (Lu 28-179) is a sigma receptor agonist, selective for the σ2 subtype with IC50 values of 0.12 nM and 17 nM for σ2 and σ1 receptors respectively.
E7418^New	Noscapine	Noscapine ((S,R)-Noscapine) is an alkaloid derived from the opium poppy (Papaver somniferum) and is a centrally acting antitussive opiate derivative. It is a non-competitive antagonist of the bradykinin B2 receptor. It also exhibits neuroprotection by activating sigma-1 opioid receptors, which help suppress intracellular NO levels and calcium, thereby providing protection against ischemic injury.
S0106	BD-1047 dihydrobromide	BD-1047 dihydrobromide (HBr) is a selective functional antagonist of sigma-1 (σ1) receptor, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia.	Brain Res, 2024, 1838:149011 Authorea Preprints, 2023, Neuropharmacology, 2021, 196:108360
E0388	WQ 1	WQ 1 is a high affinity and selective σ1 receptor antagonist with pKi values of 10.85, 6.53 and 5.80 at σ1, σ2 receptors and dopamine transporter (DAT), displaying σ1/σ2 selectivity ratio of 20893.
S0191	BD1063 2HCL	BD1063 2HCL (BD1063 dihydrochloride) is a potent and selective sigma-1 receptor (σ1R) antagonist with Ki of 4.43 nM.
S6754	S1RA	S1RA (E-52862) is a selective sigma-1 receptor (σ1R) antagonist with a reported binding affinity of Ki = 17.0 ± 7.0 nM for human σ1 receptor , selective over the sigma-2 receptor and against a panel of other 170 receptors, enzymes, transporters and ion channels.	Int Immunopharmacol, 2024, 128:111524
S0295	Anavex 2-73 HCl	Anavex 2-73 (Blarcamesine, AVex-73, AE-37), an aminotetrahydrofuran derivative, is a mixed muscarinic and sigma-1/σ₁ Receptor agonist with IC50 of 0.86 μM.
S0869	Carbetapentane	Carbetapentane (Pentoxyverine, CB) is an antitussive anticonvulsant nonselective sigma-1 (σ1) agonist.
S6561	4-IBP	4-IBP is a selective σ1 receptor agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM).
S2917	Cutamesine Dihydrochloride	Cutamesine dihydrochloride (SA4503 dihydrochloride,AGY94806 dihydrochloride) is a potent Sigma-1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes.
S6950	PRE-084 hydrochloride	PRE-084 hydrochloride (HCl) is a potent, selective sigma-1 receptor (σ1, S1R) agonist with IC50 of 44 nM in the sigma receptor assay.	Free Radic Biol Med, 2025, 226:96-108
S6756	Siramesine HCl	Siramesine (Lu 28-179) is a sigma receptor agonist, selective for the σ2 subtype with IC50 values of 0.12 nM and 17 nM for σ2 and σ1 receptors respectively.
E7418^New	Noscapine	Noscapine ((S,R)-Noscapine) is an alkaloid derived from the opium poppy (Papaver somniferum) and is a centrally acting antitussive opiate derivative. It is a non-competitive antagonist of the bradykinin B2 receptor. It also exhibits neuroprotection by activating sigma-1 opioid receptors, which help suppress intracellular NO levels and calcium, thereby providing protection against ischemic injury.

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