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Glycerol phenylbutyrate

Name: Glycerol phenylbutyrate
Brand: Selleck Chemicals
SKU: S6981
Rating: 5 (1 reviews)

Synonyms: GT4P, HPN-100M, Ravicti

Catalog No.S6981 Purity:99.58%

Glycerol phenylbutyrate (GT4P, HPN-100M, Ravicti) is a nitrogen-binding agent and acts as a sigma-2 (σ2) receptor ligand with a pKi of 8.02. Glycerol phenylbutyrate is a prodrug in which phenylbutyrate (PBA) is released from the glycerol backbone by lipases in the gastrointestinal tract.

Glycerol phenylbutyrate Chemical Structure

CAS No. 611168-24-2

Purity & Quality Control

Batch: Purity: 99.58%

99.58

Glycerol phenylbutyrate Related Products

Related Targets	sigma-2 receptor	Click to Expand
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Related Compound Libraries	FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I GPCR Compound Library	Click to Expand

Biological Activity

Description

Targets

σ2 receptor ^[2]

8.02(pKi)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT05983588	Recruiting	Corticobasal Syndrome (CBS)	Technical University of Munich	December 12 2023	Phase 2
NCT05019417	Unknown status	Monocarboxylate Transporter 8 Deficiency	Kaplan Medical Center\|Weizmann Institute of Science	June 30 2021	Phase 2\|Phase 3
NCT02323100	Terminated	Cystic Fibrosis	National Jewish Health\|University of Alabama at Birmingham\|Children''s Hospital of Philadelphia\|Johns Hopkins University\|Horizon Pharma Ireland Ltd. Dublin Ireland	December 2 2018	Phase 1\|Phase 2
NCT02246218	Completed	Urea Cycle Disorder	Horizon Therapeutics LLC\|Horizon Pharma Ireland Ltd. Dublin Ireland	December 31 2014	Phase 4

References

Chemical Information & Solubility

Molecular Weight	530.65	Formula	C₃₃H₃₈O₆
CAS No.	611168-24-2	SDF	--
Density	1.13 g/mL
Smiles	O=C(CCCC1=CC=CC=C1)OCC(COC(=O)CCCC2=CC=CC=C2)OC(=O)CCCC3=CC=CC=C3
Storage (From the date of receipt)	2 years -20°C liquid	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	2 years -20°C liquid		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (188.44 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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