Home GPCR & G Protein Sigma Receptor agonist PRE-084 hydrochloride For research use only.

PRE-084 hydrochloride

Synonyms: PRE-084 HCl

PRE-084 hydrochloride (HCl) is a potent, selective sigma-1 receptor (σ1, S1R) agonist with IC50 of 44 nM in the sigma receptor assay.

PRE-084 hydrochloride Chemical Structure

PRE-084 hydrochloride Chemical Structure

CAS No. 75136-54-8

Purity & Quality Control

Batch: S695001 DMSO]71 mg/mL]false]Water]16 mg/mL]false]Ethanol]15 mg/mL]false Purity: 99.8%
99.8

PRE-084 hydrochloride Related Products

Biological Activity

Description PRE-084 hydrochloride (HCl) is a potent, selective sigma-1 receptor (σ1, S1R) agonist with IC50 of 44 nM in the sigma receptor assay.
Targets
σ1 receptor [1]

Chemical Information & Solubility

Molecular Weight 353.88 Formula

C19H28ClNO3
CAS No. 75136-54-8 SDF --
Smiles Cl.O=C(OCCN1CCOCC1)C2(CCCCC2)C3=CC=CC=C3
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 71 mg/mL ( (200.63 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 16 mg/mL

Ethanol : 15 mg/mL


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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