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Heme Oxygenase

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Heme Oxygenase Products

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Catalog No. Product Name Information Product Use Citations Product Validations
S5645 Hemin Hemin (protohemin) is an iron-containing porphyrin used in the management of porphyria attacks, particularly in acute intermittent porphyria.Hemin is an Heme oxygenase (HO)-1 inducer.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
Hum Cell, 2024, 10.1007/s13577-024-01034-5
BMC Womens Health, 2024, 24(1):476
Cell Host Microbe, 2023, 31(3):418-432.e8
S9503 Fraxetin Fraxetin (7,8-dihydroxy-6-methoxy coumarin), found in Fraxinus rhynchophylla, shows potent antioxidant activity.fraxetin alleviates lipid peroxidation, enhances hepatic antioxidant capabilities, inhibits CYP2E1 activity, and reduced the inflammatory mediators, including TNF-α and IL-1β via up-regulation of hemeoxygenase-1 (HO-1) protein.
Life (Basel), 2023, 13(5)1112
S7880 Protoporphyrin IX Zinc Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an potent, orally active and competitive heme oxygenase-1 (HO-1) inhibitor and significantly reduces the protective effects of Phloroglucinol (PG) against hydrogen peroxide.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
Nat Commun, 2024, 15(1):9050
S9221 Ferulaldehyde Ferulaldehyde (Coniferaldehyde, Ferulyl aldehyde) is a natural intermediate of polyphenol metabolism of intestinal microflora.
S5771 Sulforaphane Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2. Sulforaphane is also an inhibitor of histone deacetylase (HDAC) and NF-κB. Sulforaphane increases heme oxygenase-1 (HO-1) and reduces the levels of reactive oxygen species (ROS). Sulforaphane induces cell cycle arrest and apoptosis.,
Nucleic Acids Res, 2024, gkae761
Redox Biol, 2024, 72:103137
J Adv Res, 2024, S2090-1232(24)00422-3
E3438 Momordica grosvenori Extract Momordica Grosvenori Extract is extracted from Siraitia grosvenorii, which has antidiabetic effects by upregulating HO-1 and can be used for the treatment of diabetes.
E0526 sappanone A Sappanone A, a homoisoflavanone isolated from the heartwood of Caesalpinia sappan (Leguminosae), induces HO-1 expression by activating Nrf2 through the p38 MAPK pathway, suppresses LPS-induced NF-κB activation by suppressing the phosphorylation of RelA/p65 at Ser536, exerting its anti-inflammatory effect.
S9503 Fraxetin Fraxetin (7,8-dihydroxy-6-methoxy coumarin), found in Fraxinus rhynchophylla, shows potent antioxidant activity.fraxetin alleviates lipid peroxidation, enhances hepatic antioxidant capabilities, inhibits CYP2E1 activity, and reduced the inflammatory mediators, including TNF-α and IL-1β via up-regulation of hemeoxygenase-1 (HO-1) protein.
Life (Basel), 2023, 13(5)1112
S7880 Protoporphyrin IX Zinc Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an potent, orally active and competitive heme oxygenase-1 (HO-1) inhibitor and significantly reduces the protective effects of Phloroglucinol (PG) against hydrogen peroxide.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
Nat Commun, 2024, 15(1):9050
S5771 Sulforaphane Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2. Sulforaphane is also an inhibitor of histone deacetylase (HDAC) and NF-κB. Sulforaphane increases heme oxygenase-1 (HO-1) and reduces the levels of reactive oxygen species (ROS). Sulforaphane induces cell cycle arrest and apoptosis.,
Nucleic Acids Res, 2024, gkae761
Redox Biol, 2024, 72:103137
J Adv Res, 2024, S2090-1232(24)00422-3
E0526 sappanone A Sappanone A, a homoisoflavanone isolated from the heartwood of Caesalpinia sappan (Leguminosae), induces HO-1 expression by activating Nrf2 through the p38 MAPK pathway, suppresses LPS-induced NF-κB activation by suppressing the phosphorylation of RelA/p65 at Ser536, exerting its anti-inflammatory effect.
E3438 Momordica grosvenori Extract Momordica Grosvenori Extract is extracted from Siraitia grosvenorii, which has antidiabetic effects by upregulating HO-1 and can be used for the treatment of diabetes.

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