GPCR19

GPCR19 Products

All (7)
GPCR19 Activators (2)
GPCR19 Antagonist (1)
GPCR19 Agonists (4)
New GPCR19 Products

Catalog No.	Product Name	Information	Product Use Citations
S6806	SBI-115	SBI-115 is a novel TGR5 (GPCR19) antagonist. SBI-115 decreases cell proliferation, cholangiocyte spheroid growth and cAMP levels in cystic cholangiocytes.	Cells, 2023, 12(4)526 Nat Commun, 2022, 13(1):3419 Cell Death Discov, 2021, 7(1):207
S4689	Deoxycholic acid	Deoxycholic acid (Deoxycholate, Desoxycholic acid, Cholerebic, Cholorebic) is a cytolytic agent. The physiologic effect of deoxycholic acid is by means of decreased cell membrane integrity. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.	Phytomedicine, 2024, 135:156251 Bio Protoc, 2022, 12(20)e4533
S0193	TGR5 Receptor Agonist	TGR5 Receptor Agonist (TGR5, CCDC, MDK00245, compd 6) is a potent agonist of TGR5(GPCR19, GPBAR1, M-BAR). TGR5 Receptor Agonist shows improved potency with pEC50 of 6.8 and 7.5 in the U2-OS cell assay and in melanophore cells, respectively.	Research Square, 2021, 10.21203/rs.3.rs-274411/v1
S0034	BAR501	BAR501 is a potent and selective G protein-coupled bile acid receptor 1 (GPBAR1, GPCR19, TGR5) agonist that effectively transactivates GPBAR1 in HEK293 cells overexpressing a CRE along with GPBAR1 with EC50 of 1 μM.
S2311	Hyodeoxycholic acid (HDCA)	Hyodeoxycholic (HDCA, NSC 60672) acid is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria.
S3069	Deoxycholic acid sodium salt	Deoxycholic acid sodium salt (Sodium Deoxycholate, Sodium Desoxycholate, Cholanoic Acid, ATX-101, Kythera, Belkyra, DCA) is specifically responsible for activating the TGR5 receptor (GPCR19) that stimulates brown adipose tissue (BAT) thermogenic activity.
S6741	SB-756050	SB-756050 is a selective TGR5 agonist (EC50 = 1.3 μM for the human receptor).
S4689	Deoxycholic acid	Deoxycholic acid (Deoxycholate, Desoxycholic acid, Cholerebic, Cholorebic) is a cytolytic agent. The physiologic effect of deoxycholic acid is by means of decreased cell membrane integrity. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.	Phytomedicine, 2024, 135:156251 Bio Protoc, 2022, 12(20)e4533
S3069	Deoxycholic acid sodium salt	Deoxycholic acid sodium salt (Sodium Deoxycholate, Sodium Desoxycholate, Cholanoic Acid, ATX-101, Kythera, Belkyra, DCA) is specifically responsible for activating the TGR5 receptor (GPCR19) that stimulates brown adipose tissue (BAT) thermogenic activity.
S6806	SBI-115	SBI-115 is a novel TGR5 (GPCR19) antagonist. SBI-115 decreases cell proliferation, cholangiocyte spheroid growth and cAMP levels in cystic cholangiocytes.	Cells, 2023, 12(4)526 Nat Commun, 2022, 13(1):3419 Cell Death Discov, 2021, 7(1):207
S0193	TGR5 Receptor Agonist	TGR5 Receptor Agonist (TGR5, CCDC, MDK00245, compd 6) is a potent agonist of TGR5(GPCR19, GPBAR1, M-BAR). TGR5 Receptor Agonist shows improved potency with pEC50 of 6.8 and 7.5 in the U2-OS cell assay and in melanophore cells, respectively.	Research Square, 2021, 10.21203/rs.3.rs-274411/v1
S0034	BAR501	BAR501 is a potent and selective G protein-coupled bile acid receptor 1 (GPBAR1, GPCR19, TGR5) agonist that effectively transactivates GPBAR1 in HEK293 cells overexpressing a CRE along with GPBAR1 with EC50 of 1 μM.
S2311	Hyodeoxycholic acid (HDCA)	Hyodeoxycholic (HDCA, NSC 60672) acid is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria.
S6741	SB-756050	SB-756050 is a selective TGR5 agonist (EC50 = 1.3 μM for the human receptor).

Choose Selective GPCR19 Inhibitors