Home GPCR & G Protein GPCR19 antagonist SBI-115 For research use only.

SBI-115

SBI-115 is a novel TGR5 (GPCR19) antagonist. SBI-115 decreases cell proliferation, cholangiocyte spheroid growth and cAMP levels in cystic cholangiocytes.

SBI-115 Chemical Structure

SBI-115 Chemical Structure

CAS No. 882366-16-7

Purity & Quality Control

Batch: S680601 DMSO]68 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.61%
99.61

SBI-115 Related Products

Biological Activity

Description SBI-115 is a novel TGR5 (GPCR19) antagonist. SBI-115 decreases cell proliferation, cholangiocyte spheroid growth and cAMP levels in cystic cholangiocytes.
Targets
TGR5 [1]
In vitro
In vitro

SBI-115, an inhibitor of TGR5, abolishes UDCA induced inhibition on cell growth (HCT116 cells, SW480 cells).[1]
Cell Research Cell lines HCT116 cells, SW480 cells
Concentrations 100μM
Incubation Time 24 h
Method

HCT116 and SW480 cells are pretreated with 100μM TGR5 antagonist SBI-115 for 24 h, and then treated with UDCA for 36 h. Cell proliferation is measured using MTT assays.

Chemical Information & Solubility

Molecular Weight 340.78 Formula

C14H13ClN2O4S
CAS No. 882366-16-7 SDF --
Smiles CCS(=O)(=O)C1=NC=C(C(=N1)C(=O)OC2=CC=CC(=C2)C)Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 68 mg/mL ( (199.54 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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